125816-10-6Relevant articles and documents
Renin inhibitors
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, (2008/06/13)
A renin inhibiting compound of the formula: STR1 wherein X is O, NH or S and G is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof; with the proviso that the compound is not N-(3-(4-M
Synthesis of renin inhibitors possessing hydroxyethylene isostere residue from 3,4,6-tri-O-acetyl-D-glucal via lactone precursor
Shiozaki,Kobayashi,Hata,Furukawa
, p. 2785 - 2800 (2007/10/02)
Syntheses of precursors for renin inhibitors possessing hydroxyethylene isostere residue from 2,4,6-tri-O-acetyl-D-glucal via lactone precursor is described . This route makes it possible to synthesize analogues with various substituents at C-2 and C-5 of
The stereospecific preparation of a hydroxyethylene isostere precursor via a novel piperidine-2,5-dione template
Plata,Leanna,Morton
, p. 3623 - 3626 (2007/10/02)
Hydroxyethylene isostere precursor 2 was synthesized by stereochemical manipulation of a novel ketolactam 'template'. The final product was prepared in very high enantiomeric purity, in 23% overall yield from L-phenylalanine.