1258391-83-1

Basic information

• Product Name: 3-(2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazolo[5,4-b]pyridin-5-yl)-N-(3-(trifluoromethyl)phenyl)benzamide
• CAS NO: 1258391-83-1
• Molecular Weight: 590.632
• Mol File: 1258391-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazolo[5,4-b]pyridin-5-yl)-N-(3-(trifluoromethyl)phenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazolo[5,4-b]pyridin-5-yl)-N-(3-(trifluoromethyl)phenyl)benzamide(1258391-83-1)
• EPA Substance Registry System: 3-(2-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazolo[5,4-b]pyridin-5-yl)-N-(3-(trifluoromethyl)phenyl)benzamide(1258391-83-1)

Safety Data

• Hazardous Substances Data: 1258391-83-1(Hazardous Substances Data)

Upstream product

• 1258391-94-4 ethyl 3-(2-aminothiazolo[5,4-b]pyridin-5-yl)benzoate 
• 1258391-93-3 ethyl 3-(2-(methylsulfonyl)thiazolo[5,4-b]pyridin-5-yl)benzoate 
• 1258391-92-2 ethyl 3-(2-(methylthio)thiazolo[5,4-b]pyridin-5-yl)benzoate 
• 1258391-91-1 ethyl 3-(5-amino-6-bromopyridin-2-yl)benzoate 
• 1258391-90-0 ethyl 3-(5-aminopyridin-2-yl)benzoate 
• 203519-37-3 tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate 
• 1258391-98-8 3-(2-aminothiazolo[5,4-b]pyridin-5-yl)-N-(3-(trifluoromethyl)phenyl)benzamide 

Relevant articles and documents

Development of 'DFG-out' inhibitors of gatekeeper mutant kinases

HG-7-85-01(22) and HG-7-86-01(26) are thiazolo[5,4-b]pyridine containing type II tyrosine kinase inhibitors with potent cellular activity against both wild-type and 'gatekeeper' mutant T315I- Bcr-Abl. Here we report on the 'hybrid design' concept and subs