1258536-45-6 Usage
Description
D4-α-cyano-4-hydroxycinnamic acid is a crystalline chemical compound with a molecular formula of C10H7NO3 and a molecular weight of 189.17 g/mol. It is commonly used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry due to its strong UV absorption at a wavelength of 337 nm.
Uses
Used in Mass Spectrometry:
D4-α-cyano-4-hydroxycinnamic acid is used as a matrix in MALDI-MS for the analysis of small organic molecules, peptides, and proteins. Its strong UV absorption at 337 nm makes it suitable for this application.
Used in Proteomics:
In the field of proteomics, D4-α-cyano-4-hydroxycinnamic acid is utilized for the analysis of proteins, aiding in the identification and characterization of proteomes.
Used in Pharmaceutical Research:
D4-α-cyano-4-hydroxycinnamic acid serves as a tool in drug discovery and development, contributing to the synthesis of organic compounds and the advancement of pharmaceutical agents.
Used in Organic Synthesis:
This chemical compound is also employed in the synthesis of various organic compounds, playing a role in the creation of new chemical entities and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 1258536-45-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,8,5,3 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1258536-45:
(9*1)+(8*2)+(7*5)+(6*8)+(5*5)+(4*3)+(3*6)+(2*4)+(1*5)=176
176 % 10 = 6
So 1258536-45-6 is a valid CAS Registry Number.
1258536-45-6Relevant articles and documents
Deuterated matrix-assisted laser desorption ionization matrix uncovers masked mass spectrometry imaging signals of small molecules
Shariatgorji, Mohammadreza,Nilsson, Anna,Goodwin, Richard J. A.,Svenningsson, Per,Schintu, Nicoletta,Banka, Zoltan,Kladni, Laszlo,Hasko, Tibor,Szabo, Andras,Andren, Per E.
, p. 7152 - 7157 (2012/11/07)
D4-α-Cyano-4-hydroxycinnamic acid (D4-CHCA) has been synthesized for use as a matrix for matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) and MALDI-MS imaging (MSI) of small molecule drugs and endogenous compounds. MALDI-MS analysis of small molecules has historically been hindered by interference from matrix ion clusters and fragment peaks that mask signals of low molecular weight compounds of interest. By using D4-CHCA, the cluster and fragment peaks of CHCA, the most common matrix for analysis of small molecules, are shifted by + 4, + 8 and + 12 Da, which expose signals across areas of the previously concealed low mass range. Here, obscured MALDI-MS signals of a synthetic small molecule pharmaceutical, a naturally occurring isoquinoline alkaloid, and endogenous compounds including the neurotransmitter acetylcholine have been unmasked and imaged directly from biological tissue sections.
