1258542-86-7

Basic information

• Product Name: 4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)benzonitrile
• Synonyms: 4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)benzonitrile
• CAS NO: 1258542-86-7
• Molecular Weight: 220.233
• Mol File: 1258542-86-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)benzonitrile(1258542-86-7)
• EPA Substance Registry System: 4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)benzonitrile(1258542-86-7)

Safety Data

• Hazardous Substances Data: 1258542-86-7(Hazardous Substances Data)

Upstream product

• 274-80-6 [1,2,4]triazolo[4,3-a]pyridine 
• 3058-39-7 4-iodobenzonitrile 
• 4930-98-7 pyrid-2-ylhydrazine 
• 105-07-7 4-cyanobenzaldehyde 
• 619-65-8 4-cyanobenzoic Acid 
• 176661-99-7 4-(2-pyridin-2-yl-hydrazonomethyl)-benzonitrile 

Relevant articles and documents

A Convenient One-pot Synthesis of N-Fused 1,2,4-Triazoles via Oxidative Cyclization Using Trichloroisocyanuric Acid

A facile one-pot synthesis of N-fused 1,2,4-triazoles from heterocyclic hydrazines and aldehydes is reported. The reaction is efficiently promoted by trichloroisocyanuric acid to afford the desired products mostly in high yields and in relatively short time. The mild nature of the synthesis and short reaction time are notable advantages of the developed protocol. This protocol is effective toward various substrates having different functionalities.

Electrochemical synthesis of 1,2,4-triazole-fused heterocycles

A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization

A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio