1258551-29-9

Basic information

• Product Name: acetic acid 5-acetoxy-7-hydroxy-2-(2-methyl-2-phenylbenzo-[1,3]dioxol-5-yl)-4-oxo-4H-chromen-3-yl ester
• Synonyms: acetic acid 5-acetoxy-7-hydroxy-2-(2-methyl-2-phenylbenzo-[1,3]dioxol-5-yl)-4-oxo-4H-chromen-3-yl ester
• CAS NO: 1258551-29-9
• Molecular Weight: 550.521
• Mol File: 1258551-29-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: acetic acid 5-acetoxy-7-hydroxy-2-(2-methyl-2-phenylbenzo-[1,3]dioxol-5-yl)-4-oxo-4H-chromen-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid 5-acetoxy-7-hydroxy-2-(2-methyl-2-phenylbenzo-[1,3]dioxol-5-yl)-4-oxo-4H-chromen-3-yl ester(1258551-29-9)
• EPA Substance Registry System: acetic acid 5-acetoxy-7-hydroxy-2-(2-methyl-2-phenylbenzo-[1,3]dioxol-5-yl)-4-oxo-4H-chromen-3-yl ester(1258551-29-9)

Safety Data

• Hazardous Substances Data: 1258551-29-9(Hazardous Substances Data)

Upstream product

• 117-39-5 quercetol 
• 2051-90-3 Dichlorodiphenylmethane 
• 357194-03-7 2-(2,2-diphenylbenzo[1,3]dioxol-5-yl)-3,5,7-trihydroxychromen-4-one 
• 1258551-28-8 acetic acid 3,5-diacetoxy-2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-4-oxo-4H-chromen-7-yl ester 

Downstream Products

• 1258551-30-2 acetic acid 5-acetoxy-7-benzyloxy-2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-4-oxo-4H-chromen-3-yl ester 
• 49570-46-9 7-benzyloxy-2-(2,2-diphenyl-benzo[1,3]dioxol-5-yl)-3,5-dihydroxy-chromen-4-one 
• 1310686-94-2 C₂₀H₁₈O₁₀ 

Relevant articles and documents

New lipophenols prevent carbonyl and oxidative stresses involved in macular degeneration

Dry age-related macular degeneration and Stargardt disease undergo a known toxic mechanism caused by carbonyl and oxidative stresses (COS). This is responsible for accumulation in the retinal pigment epithelium (RPE) of A2E, a main toxic pyridinium bis-retinoid lipofuscin component. Previous studies have shown that carbonyl stress in retinal cells could be reduced by an alkyl-phloroglucinol-DHA conjugate (lipophenol). Here, we performed a rational design of different families of lipophenols to conserve anti-carbonyl stress activities and improve antioxidant properties. Five synthetic pathways leading to alkyl-(poly)phenol derivatives, with phloroglucinol, resveratrol, catechin and quercetin as the main backbone, linked to poly-unsaturated fatty acid, are presented. These lipophenols were evaluated in ARPE-19 cell line for their anti-COS properties and a structure-activity relationship study is proposed. Protection of ARPE-19 cells against A2E toxicity was assessed for the four best candidates. Finally, interesting anti-COS properties of the most promising quercetin lipophenol were confirmed in primary RPE cells.

Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance

Quercetin-amino acid conjugates with alanine or glutamic acid moiety attached at 7-O and/or 3-O position of quercetin were prepared, and their multidrug resistance (MDR)-modulatory effects were evaluated. A quercetin-glutamic acid conjugate, 7-O-Glu-Q (3a

Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety

In order to increase stability of quercetin, its metabolically and chemically susceptible hydroxyl groups 7-OH and 3-OH respectively were transiently blocked with a pivaloxymethyl (POM) promoiety to provide two novel quercetin conjugates [7-O-POM-Q (2), 3