125867-26-7

Basic information

• Product Name: N-(3-(hydroxy(phenyl)methyl)pyridin-4-yl)pivalamide
• Synonyms: N-(3-(hydroxy(phenyl)methyl)pyridin-4-yl)pivalamide
• CAS NO: 125867-26-7
• Molecular Weight: 284.358
• Mol File: 125867-26-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(3-(hydroxy(phenyl)methyl)pyridin-4-yl)pivalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(hydroxy(phenyl)methyl)pyridin-4-yl)pivalamide(125867-26-7)
• EPA Substance Registry System: N-(3-(hydroxy(phenyl)methyl)pyridin-4-yl)pivalamide(125867-26-7)

Safety Data

• Hazardous Substances Data: 125867-26-7(Hazardous Substances Data)

Usage

General Description

N-(3-(hydroxy(phenyl)methyl)pyridin-4-yl)pivalamide is an organic compound with the chemical formula C17H20N2O2. This chemical contains different functional groups like an amide, hydroxyl group, phenyl group, and a pyridine ring. It is a pivalamide derivative with potential applications in the field of medicine and pharmacology. The compound may possess certain biological activities due to its structure, and it could be used in drug discovery and development. Further research and studies are required to fully understand the properties and potential uses of N-(3-(hydroxy(phenyl)methyl)pyridin-4-yl)pivalamide.

Upstream product

• 504-24-5 4-aminopyridine 
• 3282-30-2 pivaloyl chloride 
• 70298-89-4 4-N-pivaloylaminopyridine 
• 100-52-7 benzaldehyde 

Downstream Products

• 3810-12-6 (4-aminopyridin-3-yl)(phenyl)methanone 
• 116922-81-7 10-phenyl-6,7,8,9-tetrahydrobenzo<1,6>naphthyridine 
• 125867-43-8 4-phenyl-1,2-dihydropyrido<4,3-d>-2-pyrimidinone 
• 125867-35-8 phenyl (4-pivaloylamino-3-pyridyl) ketone 

Relevant articles and documents

Synthesis and biological assessment of 4,1-benzothiazepines with neuroprotective activity on the Ca2+ overload for the treatment of neurodegenerative diseases and stroke

In excitable cells, mitochondria play a key role in the regulation of the cytosolic Ca2+ levels. A dysregulation of the mitochondrial Ca2+ buffering machinery derives in serious pathologies, where neurodegenerative diseases highlight. Since the mitochondrial Na+/Ca2+ exchanger (NCLX) is the principal efflux pathway of Ca2+ to the cytosol, drugs capable of blocking NCLX have been proposed to act as neuroprotectants in neuronal damage scenarios exacerbated by Ca2+ overload. In our search of optimized NCLX blockers with augmented drug-likeness, we herein describe the synthesis and pharmacological characterization of new benzothiazepines analogues to the first-in-class NCLX blocker CGP37157 and its further derivative ITH12575, synthesized by our research group. As a result, we found two new compounds with an increased neuroprotective activity, neuronal Ca2+ regulatory activity and improved drug-likeness and pharmacokinetic properties, such as clog p or brain permeability, measured by PAMPA experiments.

COMPOUNDS

The present invention provides a compound incorporating a group of formula (I) wherein: 1 of X, Y and Z is nitrogen and the other 2 are carbon; R" is hydrogen, methyl, ethyl or propyl; and W represents hydrogen, carbon, nitrogen, oxygen or sulphur; or incorporating a salt, hydrate or solvate of a group of formula (I); as well as therapeutic uses of these compounds, in particular as inhibitors of protein kinase activity and in the treatment of inflammation, inflammatory conditions and cancer.

Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives

The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.