1258740-26-9

Basic information

• Product Name: (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid
• Synonyms: (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid
• CAS NO: 1258740-26-9
• Molecular Weight: 363.434
• Mol File: 1258740-26-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid(1258740-26-9)
• EPA Substance Registry System: (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoic acid(1258740-26-9)

Safety Data

• Hazardous Substances Data: 1258740-26-9(Hazardous Substances Data)

Upstream product

• 1258740-11-2 tert-butyl (R)-4-(3-methoxyphenyl)-3-(4-methylphenylsulfonamido)butanoate 

Downstream Products

• 3588-75-8 8-methoxy-naphthalen-1-ol 
• 22604-07-5 6-methoxy-1-naphthol 
• 1258740-37-2 (R)-N-(7-methoxy-4-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-methylbenzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 

Relevant articles and documents

Synthesis of substituted (S)-2-aminotetralins via ring-opening of aziridines prepared from l-aspartic acid β-tert-butyl ester

This paper describes the total synthesis of the hydrochloride salts of (2S)-2-amino-7-methoxytetralin (21-HCl) and (2S)-2-amino-6-fluoro-7- methoxytetralin (ST1214), from a common enantiomerically pure aziridine 4b, which was available from l-aspartic acid β-tert-butyl ester. The synthesis of 21-HCl and ST1214 proceeded in nine steps and 5 and 6% overall yields, respectively. Key steps are the regioselective ring-opening of 4b with ArMgBr/CuBr·SMe2 and the intramolecular Friedel-Crafts cyclisation providing α-tetralone. Substituted naphthalenes were formed as side products in the latter reaction.