1258856-14-2Relevant articles and documents
Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists
Taylor, Simon J.,Demont, Emmanuel H.,Gray, James,Deeks, Nigel,Patel, Aarti,Nguyen, Dung,Taylor, Maxine,Hood, Steve,Watson, Robert J.,Bit, Rino A.,McClure, Fiona,Ashall, Holly,Witherington, Jason
, p. 8236 - 8256 (2015/11/09)
This article describes the finding of substantial upregulation of mRNA and enzymes of the cytochrome P450 1A family during a lead optimization campaign for small molecule S1P1 agonists. Fold changes in mRNA up to 10 000-fold for CYP1A1 in vivo