1258943-41-7Relevant articles and documents
Synthesis of P,N-2,2′-biphenyl derivatives with central chirality
Jean, Ludovic,Pouliquen, Michael,Blanchet, Jerome,Lasne, Marie-Claire,Rouden, Jacques
experimental part, p. 1907 - 1913 (2011/01/12)
Enantiopure 2-(dicyclohexylphosphino)-1,1′-biphenyl derivatives substituted in the 2′-position by a chiral amino group were prepared. For the compound bearing an acyclic chiral chain, the key step was a Suzuki coupling between bromobenzeneboronic acid and N-Boc-iodoaniline whereas an aromatic nucleophilic substitution allowed the introduction of a chiral pyrrolidine in the 2′-position of the biphenyl backbone. The efficiency of the P,N-biphenyl pyrrolidine derivatives as ligands in Pd-catalyzed arylaminations compares well with that of DavePhos ligand.
