125902-27-4 Usage
Description
(1,8-naphthyridin-2-yl)methanol is a chemical compound with the molecular formula C12H9NO. It is a naphthyridine derivative that contains a hydroxyl group. (1,8-naphthyridin-2-yl)methanol is characterized by the presence of a naphthyridine moiety, which suggests potential biological activities and makes it a promising molecule for drug discovery and development.
Uses
Used in Organic Synthesis:
(1,8-naphthyridin-2-yl)methanol is used as a building block in organic synthesis for the creation of various compounds. Its unique structure allows for the formation of new chemical entities with potential applications in different fields.
Used in Medicinal Chemistry:
(1,8-naphthyridin-2-yl)methanol is used as a starting material in medicinal chemistry for the development of new pharmaceuticals. The presence of the naphthyridine moiety in its structure may contribute to its potential biological activities, making it a valuable component in the synthesis of novel therapeutic agents.
Used in Drug Discovery and Development:
(1,8-naphthyridin-2-yl)methanol is used as a key intermediate in drug discovery and development processes. Its potential biological activities and unique structural features make it an important molecule for the design and synthesis of new drugs with therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 125902-27-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,9,0 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 125902-27:
(8*1)+(7*2)+(6*5)+(5*9)+(4*0)+(3*2)+(2*2)+(1*7)=114
114 % 10 = 4
So 125902-27-4 is a valid CAS Registry Number.
125902-27-4Relevant articles and documents
Functionalization of 2-Methyl- and 2,7-Dimethyl-1,8-naphthyridine
Newkome, George R.,Theriot, Kevin J.,Majestic, Veronica K.,Spruell, Perri Anne,Baker, Gregory R.
, p. 2838 - 2842 (1990)
A new synthesis of 2,7-dimethyl-1,8-naphthyridine (dmnap) from 2-methyl-1,8-naphthyridine (mnap) upon treatment with 3 equiv of methyllithium is described.Oxidation of dmnap with 8 equiv of N-chlorosuccinimide gave (98percent) 2,7-bis(trichloromethyl)-1,8-naphthyridine (2), while oxidation with 4 equiv gave (97percent) 2,7-bis(dichloromethyl)-1,8-naphthyridine (1).Hydrolysis of 2 phosphoric acid followed by esterification gave the corresponding diester 3 in 80percent overall yield.Reduction of 3 with NaBH(OMe)3 afforded (55percent) diol 4.Similar functionalization of mnap afforded 2-(trichloromethyl)-1,8-naphthyridine (6) in 85-94percent yield along with 6-chloro-2-(trichloromethyl)-1,8-naphthyridine (7).Methanolysis of 6 gave (78percent) 2-(methoxycarbonyl)-1,8-naphthyridine (8), which upon reduction with NaBH(OMe)3 afforded (59percent) the alcohol 9.Treatment of 6 with KOH caused a displacement of the trichloromethyl moiety, generating 1,8-naphthyridin-2-one (10) as the sole product.Similarly, 2 gave 7-(trichloromethyl)-1,8-naphthyridin-2-one (11) under mild conditions or 7-(ethoxycarbonyl)-1,8-naphthyridin-2-one (12) when refluxed.
