125911-68-4

Basic information

• Product Name: SAMS PEPTIDE
• Synonyms: (SER76,ARG86,87)-ACC-ALPHA (73-87) (DEPHOSPHORYLATED) (E COLI, RAT);(SER76,ARG86,87)-ACETYL-COA CARBOXYLASE 1 (73-87) (DEPHOSPHORYLATED) (E COLI, RAT);(SER77,ARG87,88)-ACC-ALPHA (74-88) (DEPHOSPHORYLATED) (BOVINE, OVINE);(SER77,ARG87,88)-ACETYL-COA CARBOXYLASE 1 (74-88) (DEPHOSPHORYLATED) (BOVINE, OVINE);SAMS PEPTIDE;HIS-MET-ARG-SER-ALA-MET-SER-GLY-LEU-HIS-LEU-VAL-LYS-ARG-ARG;HMRSAMSGLHLVKRR;H-HIS-MET-ARG-SER-ALA-MET-SER-GLY-LEU-HIS-LEU-VAL-LYS-ARG-ARG-OH
• CAS NO: 125911-68-4
• Molecular Formula: C74H131N29O18S2
• Molecular Weight: 1779.15
• Product Categories: Peptide;Protein Kinase;Signalling
• Mol File: 125911-68-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.47±0.1 g/cm3(Predicted)
• Storage Temp.: Desiccate at -20°C
• CAS DataBase Reference: SAMS PEPTIDE(CAS DataBase Reference)
• NIST Chemistry Reference: SAMS PEPTIDE(125911-68-4)
• EPA Substance Registry System: SAMS PEPTIDE(125911-68-4)

Safety Data

• Hazardous Substances Data: 125911-68-4(Hazardous Substances Data)

Usage

Description

SAMS Peptide is a unique peptide that features a putative AMPK phosphorylation site (Ser568) of carbohydrate-responsive element-binding protein (ChREBP) and a peptide containing a cAMP-dependent protein kinase (PKA) phosphorylation site (Thr666). This peptide plays a significant role in cellular processes and holds potential for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
SAMS Peptide is used as a research tool for studying the phosphorylation events and interactions of AMPK and PKA with ChREBP. This helps in understanding the regulation of cellular processes and the development of targeted therapies for various diseases.
Used in Biotechnology Industry:
SAMS Peptide serves as a key component in the development of novel drug delivery systems and therapeutic strategies. By targeting the specific phosphorylation sites, it can enhance the efficacy of existing treatments and contribute to the creation of innovative biotechnological solutions.
Used in Diagnostics:
SAMS Peptide can be employed in the development of diagnostic tools and assays to detect and monitor the activity of AMPK and PKA in various disease states. This can aid in the early detection and personalized treatment of conditions related to these kinases.
Used in Research and Development:
SAMS Peptide is used as a valuable research tool in academic and industrial laboratories to study the molecular mechanisms underlying the regulation of cellular processes by AMPK and PKA. This can lead to the discovery of new therapeutic targets and the development of novel drugs for various diseases.

Biochem/physiol Actions

SAMS Peptide is a synthetic substrate selective for AMP-activated protein kinase (AMPK). Its sequence is based on acetyl-CoA carboxylase, which is phosphorylated exclusively by the AMPK, but with serine (Ser)-79 replaced by alanine SAMS peptide is more specific for AMPK than acetyl-CoA carboxylase itself.