1259300-52-1

Basic information

• Product Name: 4-(1H-indazol-3-ylamino)-2-phenyl-2H-phthalazin-1-one
• CAS NO: 1259300-52-1
• Molecular Weight: 353.383
• Mol File: 1259300-52-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(1H-indazol-3-ylamino)-2-phenyl-2H-phthalazin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-indazol-3-ylamino)-2-phenyl-2H-phthalazin-1-one(1259300-52-1)
• EPA Substance Registry System: 4-(1H-indazol-3-ylamino)-2-phenyl-2H-phthalazin-1-one(1259300-52-1)

Safety Data

• Hazardous Substances Data: 1259300-52-1(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 19064-73-4 4-bromo-2H-phthalazin-1-one 
• 874-05-5 3-aminoindazole 

Relevant articles and documents

Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase

The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds (typically >1000-fold selectivity over Aurora-B) that display good pharmacological profiles with significantly improved oral bioavailability compared to the well studied Aurora inhibitor VX-680.