1259890-94-2

Basic information

• Product Name: 5-chloro-7-(4-methoxyphenyl)indole
• Synonyms: 5-chloro-7-(4-methoxyphenyl)indole
• CAS NO: 1259890-94-2
• Molecular Weight: 257.719
• Mol File: 1259890-94-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-7-(4-methoxyphenyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-7-(4-methoxyphenyl)indole(1259890-94-2)
• EPA Substance Registry System: 5-chloro-7-(4-methoxyphenyl)indole(1259890-94-2)

Safety Data

• Hazardous Substances Data: 1259890-94-2(Hazardous Substances Data)

Upstream product

• 4792-72-7 5,7-dichloro-1H-indole 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Relevant articles and documents

Site-selective cross-coupling of dichlorinated benzo-fused nitrogen-heterocycles with Grignard reagents

Site-selective cross-coupling of dihaloarenes constitutes a useful method for synthesis of multi-substituted arenes. In this paper, we report the site-selective cross-coupling of dichlorinated benzo-fused nitrogen-heterocycles having two chloro groups on the benzene ring. These dichlorinated heterocycles reacted with Grignard reagents in the presence of PdCl2(PCy 3)2 at the positions ortho to the nitrogen-based substituents with high selectivities. A mechanism in which interaction between Lewis acidic Mg and Cl of the ortho position facilitates C-Cl bond cleavage is proposed.