125996-71-6

Basic information

• Product Name: 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE
• Synonyms: 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE
• CAS NO: 125996-71-6
• Molecular Formula: C₁₄H₁₀F₃NO
• Molecular Weight: 265.23
• Mol File: 125996-71-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE(125996-71-6)
• EPA Substance Registry System: 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE(125996-71-6)

Safety Data

• Hazardous Substances Data: 125996-71-6(Hazardous Substances Data)

Usage

General Description

The chemical 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE is a compound with a molecular structure consisting of a pyridine ring connected to a trifluoromethyl-phenyl group by a ketone functional group. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE exhibits both aromatic and carbonyl functional groups, allowing it to participate in a wide range of chemical reactions. It may also have potential applications in medicinal and biological chemistry due to the presence of the pyridine moiety, which is a common structural motif in many pharmaceutical agents. Additionally, the trifluoromethyl substituent can enhance the compound's biological activity and improve its chemical stability.

Upstream product

• 108-89-4 picoline 
• 583-02-8 ethyl 4-(trifluoromethyl)benzoate 
• 455-18-5 4-CF₃C₆H₄CN 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 

Downstream Products

• 125996-86-3 1-Benzyl-4-[2-oxo-2-(4-trifluoromethyl-phenyl)-ethyl]-pyridinium; bromide 
• 861804-97-9 benzyl 4-(4-oxo-3-(pyridin-4-yl)-4-(4-(trifluoromethyl)phenyl)butanoyl)piperidine-1-carboxylate 
• 861804-77-5 benzyl 4-(4-(pyridin-4-yl)-5-(4-(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)piperidine-1-carboxylate 

Relevant articles and documents

THERAPEUTIC METHODS AND COMPOUNDS

The invention provides a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein R1-R5 Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful to treat malaria.

Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38α kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position leading to analogs that were potent in human whole blood based cell assay as well as in a number of animal efficacy models for rheumatoid arthritis. Ultimately, we identified a clinical candidate from this substrate; SD-0006.

Adenosine A3 receptor antagonists

A pharmaceutical composition for antagonizing adenosine at adenosine A3receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.