126-31-8 Usage
Description
Methiodal sodium, also known by its brand names Abrodil, Myelotrast, Neo-sombraven, Sergozin, Skiodan sodium, and Urombal, is a colorless crystalline powder with an odorless and slightly salty taste followed by a sweetish aftertaste. It is a radiopaque contrast medium used in various medical applications. Methiodal sodium decomposes when exposed to light, and its solutions are neutral to litmus. It is soluble in water, very soluble in methanol, slightly soluble in alcohol, and practically insoluble in other solvents.
Uses
Used in Medical Imaging:
Methiodal sodium is used as a radiopaque contrast medium for enhancing the visibility of internal body structures during medical imaging procedures, such as X-ray examinations. Its radiopaque properties allow for better differentiation between tissues and organs, facilitating accurate diagnosis and treatment planning.
Used in Pharmaceutical Industry:
Methiodal sodium is used as an active pharmaceutical ingredient in the development of various diagnostic agents. Its properties make it suitable for use in the formulation of contrast agents for medical imaging, contributing to the advancement of diagnostic techniques and patient care.
World Health Organization (WHO)
Methiodal sodium, a radio-opaque medium, was formerly used for
the examination of the urinary tract. Its use was associated with muscle spasms
presumed to result from irritation of motor nerve roots in the spinal canal. This led
to its withdrawal in Sweden in 1975 when a safer alternative became available.
Preparations containing methiodal sodium were subsequently withdrawn
worldwide by the manufacturer.
Air & Water Reactions
Water soluble.
Reactivity Profile
Sensitive to light.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic.
Check Digit Verification of cas no
The CAS Registry Mumber 126-31-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 6 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 126-31:
(5*1)+(4*2)+(3*6)+(2*3)+(1*1)=38
38 % 10 = 8
So 126-31-8 is a valid CAS Registry Number.
InChI:InChI=1/CH3IO3S.Na/c2-1-6(3,4)5;/h1H2,(H,3,4,5);/q;+1/p-1
126-31-8Relevant articles and documents
Protocol for Stereoselective Construction of Highly Functionalized Dienyl Sulfonyl Fluoride Warheads
Zhang, Zai-Wei,Wang, Shi-Meng,Fang, Wan-Yin,Lekkala, Ravindar,Qin, Hua-Li
, p. 13721 - 13734 (2020/12/15)
A pyrrolidine-mediated Knoevenagel-type reaction for highly stereoselective construction of novel α-halo-1,3-dienylsulfonyl fluorides was achieved in up to 100% Z-selectivity and high yields at room temperature from condensation of the readily available aldehydes and halomethanesulfonyl fluorides. This protocol provided a class of unique α-halo-1,3-dienylsulfonyl fluorides with wide scope and excellent functional group compatibility. The α-halo-1,3-dienylsulfonyl fluorides were used as versatile building blocks in sulfur fluoride exchange click chemistry, Suzuki reaction, and Sonogashira reaction for the assembly of highly functionalized dienyl sulfonyl fluoride derivatives to be applied as covalent warheads for the discovery of new drugs.
α-Haloalkanesulfonyl Bromides in Organic Synthesis. 3. α-Alkylidene Ketones and 1,3-Oxathiole 3,3-Dioxides from Trimethylsilyl Enol Ethers
Block, Eric,Aslam, Mohammad,Iyer, Rajeshwari,Hutchinson, John
, p. 3664 - 3666 (2007/10/02)
α-Alkylidene ketones and 1,3-oxathiole 3,3-dioxides can be conveniently prepared by treatment of trimethylsilyl enol ethers with α-haloalkanesulfonyl bromides followed by an amine base such as 1,5-diazabicyclonon-5-ene (DBN).