1260220-67-4 Usage
Description
(S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE is a chemical compound that holds potential pharmaceutical applications. It is a pyrrolidine derivative featuring a tert-butyl ester group and an amino phenyl group, which makes it a versatile building block for drug discovery and development. Its unique structure and properties render it potentially useful in the synthesis of various pharmaceutical compounds, particularly for neurological disorders, cancer, or other therapeutic targets. Further research and development of (S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE could lead to the discovery of novel pharmaceutical agents with potential therapeutic benefits.
Uses
Used in Pharmaceutical Industry:
(S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE is used as a building block for the development of new drugs targeting neurological disorders, cancer, and other therapeutic areas. Its unique structure and properties make it a promising candidate for the synthesis of pharmaceutical compounds with potential therapeutic benefits.
Used in Drug Discovery:
(S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE is used as a versatile compound in drug discovery, where its structure can be modified and optimized to create new pharmaceutical agents with improved efficacy and safety profiles.
Used in Research and Development:
(S)-TERT-BUTYL 2-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE is utilized as a key compound in research and development efforts, where it can be studied for its potential interactions with biological targets and its ability to modulate various signaling pathways related to disease processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1260220-67-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,2,2 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1260220-67:
(9*1)+(8*2)+(7*6)+(6*0)+(5*2)+(4*2)+(3*0)+(2*6)+(1*7)=104
104 % 10 = 4
So 1260220-67-4 is a valid CAS Registry Number.
1260220-67-4Relevant articles and documents
Enantioselective, palladium-catalyzed α-arylation of N-Boc-pyrrolidine
Campos, Kevin R.,Klapars, Artis,Waldman, Jacob H.,Dormer, Peter G.,Chen, Cheng-Yi
, p. 3538 - 3539 (2006)
This communication discloses the first instance of the enantioselective Pd-catalyzed α-arylation of N-Boc-pyrrolidine. The methodology relies on Beak's sparteine-mediated, enantioselective deprotonation of N-Boc-pyrrolidine to form the 2-pyrrolidinolithium specices in high enantiomeric ratio (er). Transmetalation of this intermediate with zinc chloride generates the stereochemically rigid, 2-pyrrolidinozinc reagent, which was readily coupled to a variety of functionalized aryl halides at room temperature using a catalyst generated from Pd(OAc)2 and PtBu3-HBF4. A diverse array of 2-aryl-N-Boc-pyrrolidines was synthesized using this methodology, providing adducts consistently in a 96:4 er. A survey of the stoichiometry revealed that as little as 0.3 equiv of zinc could be used in the coupling reaction, and the 2-pyrrolidinozinc reagent was found to exhibit stereochemical stability up to 60 °C. The method allows for the most convergent and reliable preparation of a broad range of functionalized 2-aryl-N-Boc-pyrrolidines in high enantioselectivity, which is highlighted in this report by the enantioselective synthesis of (R)-nicotine. Copyright
Diamine-free lithiation-trapping of N-Boc heterocycles using s-BuLi in THF
Barker, Graeme,Obrien, Peter,Campos, Kevin R.
supporting information; experimental part, p. 4176 - 4179 (2010/11/16)
A diamine-free protocol for the s-BuLi-mediated lithiation-trapping of N-Boc heterocycles has been developed. In the optimized procedure, lithiation is accomplished using s-BuLi in THF at -30 °C for only 5 or 10 min. Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered a range of functionalized pyrrolidines, imidazolidines, and piperazines in 43-83% yield.
