1260254-02-1Relevant articles and documents
Catalytic asymmetric bromine-lithium exchange: A new tool to build axial chirality
Perron, Quentin,Alexakis, Alexandre
supporting information; experimental part, p. 2611 - 2620 (2011/01/05)
We present here the first catalytic desymmetrization of the 2,2′,6,6′-tetrabromobiphenyl 1 and analogues, by a bromine-lithium exchange catalyzed by either diamines or diether derivatives (0.5 equiv.), yielding axially chiral compounds in high yield (up to 89%) and high enantioselectivity (up to 82%).