126027-87-0Relevant articles and documents
Immobilization of theophylline on medical-grade polyurethane inhibits surface-induced activation of blood platelets
Kuijpens,Kardaun,Blezer,Pijpers,Koole
, p. 8691 - 8697 (1995)
Conjugate molecule 2, in which theophylline and a 4-azidobenzoyl group are separated by a short spacer chain, was adsorbed onto polyurethane sheets and subsequently irradiated with ultraviolet light. The resulting photoreaction at the polymer surface led
Tricyclic oxazolidone comound, and preparation method and use thereof
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Paragraph [0339], (2016/10/07)
The invention relates to a novel tricyclic oxazolidone comound, and a preparation method and a use thereof, and concretely discloses a compound with the structure represented by formula I, an enantiomer, a diastereomer or a raceme thereof or a mixture of the enantiomer, the diastereomer and the raceme, or a pharmaceutically acceptable salt thereof. The formula I is shown in the specification. The invention also discloses a preparation method of the compound, and an application of the compound in FXa target related disease treatment drugs.
Polyketide building blocks via diastereoselective nitrile oxide cycloadditions with homoallylic alcohols and monoprotected homoallylic diols
Lohse-Fraefel, Nina,Carreira, Erick M.
supporting information; experimental part, p. 12065 - 12081 (2010/05/18)
A modular approach to δ2-isoxazolines, latent aldol adducts and polyketide building blocks, is reported. The magnesium-mediated, hydroxyl-directed method allows for the diastereoselective access to a wide variety of masked β-hydroxy ketones, starting from readily available aliphatic and aromatic oximes, homoallylic alcohols and monoprotected homoallylic diols. The utility of the prepared δ2-isoxazolines as polyketide building blocks is demonstrated by their ready conversion into the corresponding β-hydroxy ketones. The anti-diastereoselectivity of the reaction was established by derivatization, NOE studies and comparison of known compounds. A rationale for the observed diastereoselectivity is proposed.