126028-17-9Relevant articles and documents
Methyltrypsin-catalyzed peptide coupling: Comparison of alkyl ester and guanidinophenyl ester derivatives as acyl donor component
Itoh, Kunihiko,Sekizaki, Haruo,Toyota, Eiko,Tanizawa, Kazutaka
, p. 307 - 319 (2007/10/03)
Methyltrypsin-catalyzed peptide synthesis has been studied by using conventional alkyl ester and p-guanidinophenyl ester derivatives of α-amino acid as the acyl donor component. They were found to be coupled with α- amino acid derivatives (acyl acceptor component) to produce dipeptide. The behavior of methyltrypsin toward both the substrates has been studied.
Cross-linked crystals of subtilisin: Versatile catalyst for organic synthesis
Wang, Yi-Fong,Yakovlevsky, Kirill,Zhang, Bailing,Margolin, Alexey L.
, p. 3488 - 3495 (2007/10/03)
Cross-linked enzyme crystals (CLECs) of subtilisin exhibit excellent activity in aqueous and various organic solvents. This catalyst is more stable than the native enzyme in both aqueous and mixed aqueous/organic solutions. Subtilisin-CLEC was shown to be a versatile catalyst. It was used for the syntheses of peptides and peptidomimetics, mild hydrolysis of amino acid and peptide amides, enantio- and regioselective reactions, and transesterifications.
ENZYMATIC PEPTIDE SYNTHESIS IN ORGANIC SOLVENT MEDIATED BY MODIFIED α-CHYMOTRYPSIN
Babonneau, Marie-Therese,Jacquier, Robert,Lazaro, Rene,Viallefont, Philippe
, p. 2787 - 2790 (2007/10/02)
Peptide couplings have been catalyzed in organic medium containing a slight amount of water (0.5percent) by PEG modified α-Chymotrypsin.
