1260667-12-6

Basic information

• Product Name: 2-amino-3-chloro-5-(trifluoromethyl)pyrazine
• CAS NO: 1260667-12-6
• Molecular Weight: 197.547
• Mol File: 1260667-12-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-amino-3-chloro-5-(trifluoromethyl)pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-chloro-5-(trifluoromethyl)pyrazine(1260667-12-6)
• EPA Substance Registry System: 2-amino-3-chloro-5-(trifluoromethyl)pyrazine(1260667-12-6)

Safety Data

• Hazardous Substances Data: 1260667-12-6(Hazardous Substances Data)

Usage

Chemical Structure

A pyrazine derivative with a trifluoromethyl group and a chlorine atom attached to a pyrazine ring

Common Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, production of fine chemicals, building block in organic synthesis

Reactivity

Versatile reactivity, leading to diverse applications in organic chemistry

Interest

Due to its specific structural properties, it attracts attention from researchers and industries for developing new chemical compounds and improving existing processes

Upstream product

• 69816-38-2 5-trifluoromethyl-pyrazin-2-ylamine 
• 799557-87-2 2-chloro-5-(trifluoromethyl)-pyrazine 

Relevant articles and documents

Intramolecular Metal-Free N?N Bond Formation with Heteroaromatic Amines: Mild Access to Fused-Triazapentalene Derivatives

Formation of N?N bonds may offer an original approach to various nitrogen-containing heterocycles with numerous applications. For this purpose, we found that readily available heteroaromatic amines are appropriate substrates for providing an efficient and innovative approach for the formation of N?N bonds in the presence of iodine (III) reagent in very mild conditions. This method makes it possible to synthesize nitrogen rich triazapentalene derivatives exhibiting fluorescent properties, inaccessible with existing approaches.

CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS

This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-y which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.