126081-03-6

Basic information

• Product Name: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester
• Synonyms: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester
• CAS NO: 126081-03-6
• Molecular Weight: 308.337
• Mol File: 126081-03-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 194 °C(Solv: ethanol (64-17-5))
• Boiling Point: 471.8±47.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)
• CAS DataBase Reference: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester(126081-03-6)
• EPA Substance Registry System: [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester(126081-03-6)

Safety Data

• Hazardous Substances Data: 126081-03-6(Hazardous Substances Data)

Usage

Description

[4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester is a chemical compound with the molecular formula C17H15NO4, derived from phenylacetic acid and phthalazinone. It is a white to off-white solid that is insoluble in water but soluble in organic solvents such as ethanol and methanol. This ester derivative is predominantly utilized in research and experimental settings, serving as a building block in the synthesis of various pharmaceuticals and organic compounds.

Uses

Used in Pharmaceutical Research and Development:
[4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester is used as a building block for the synthesis of new pharmaceuticals and organic compounds. Its application in this field is due to its potential in contributing to the development of novel drugs and treatments.
Used in Chemical Reactions and Mechanisms Study:
[4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester is also used as a research tool in the study of chemical reactions and mechanisms. Its application in this area is attributed to its unique chemical properties and reactivity, which can provide valuable insights into various chemical processes.
Used in Drug Synthesis:
[4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester is used as an intermediate in the synthesis of various drugs. Its application in this industry is due to its ability to be a key component in the creation of new and effective medications.
Used in Organic Chemistry:
In the field of organic chemistry, [4-phenyl-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester is used as a reagent for various chemical reactions. Its application in this industry is because of its solubility in organic solvents and its potential to participate in a wide range of chemical transformations.

Upstream product

• 612-35-1 2-Benzylbenzoic acid 
• 5004-45-5 4-phenyl-2H-phthalazin-1-one 
• 105-36-2 ethyl bromoacetate 
• 85-52-9 2-Benzoylbenzoic acid 
• 6945-92-2 2-hydrazinyl acetic acid ethyl ester hydrochloride 

Downstream Products

• 126081-29-6 2-[6-(4-Dimethylamino-phenyl)-5-(5,6-diphenyl-[1,2,4]triazin-3-yl)-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one 
• 126081-30-9 2-[5-(5,6-Diphenyl-[1,2,4]triazin-3-yl)-6-(2-hydroxy-phenyl)-6-methyl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one 
• 126081-43-4 2-(2-{3-[N'-(2,4-Dinitro-phenyl)-hydrazino]-5-phenyl-pyrazol-1-yl}-2-oxo-ethyl)-4-phenyl-2H-phthalazin-1-one 
• 126081-31-0 2-[5-(5,6-Diphenyl-[1,2,4]triazin-3-yl)-6-methyl-6-pyridin-4-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-ylmethyl]-4-phenyl-2H-phthalazin-1-one 
• 126081-42-3 Benzoic acid N'-{1-[2-(1-oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-5-phenyl-1H-pyrazol-3-yl}-hydrazide 
• 126081-41-2 2-{2-[3-(4-Chloro-phenylamino)-5-phenyl-pyrazol-1-yl]-2-oxo-ethyl}-4-phenyl-2H-phthalazin-1-one 
• 126081-40-1 N-{1-[2-(1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-5-phenyl-1H-pyrazol-3-yl}-benzamide 
• 126081-16-1 1(2H)-oxo-4-phenylphthalazine-2-acetic acid 4-oxo-3-phenyl-2-thiazolidinylidenehydrazide 
• 126081-35-4 1,2-bis<1'(2'H)-oxo-4'-phenylphthalazin-2'-yl>ethanone 
• 126081-05-8 4-Nitro-benzoic acid N'-[2-(1-oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-hydrazide 
• 126081-39-8 N-{1-[2-(1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetyl]-5-phenyl-1H-pyrazol-3-yl}-acetamide 
• 126081-27-4 (1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetic acid [3-[(E)-hydroxyimino]-1-phenyl-but-(Z)-ylidene]-hydrazide 
• 126081-33-2 (1-Oxo-4-phenyl-1H-phthalazin-2-yl)-acetic acid [2-oxo-1,2-diphenyl-eth-(Z)-ylidene]-hydrazide 
• 126081-12-7 2-[3-(4-Nitro-phenyl)-5-oxo-4,5-dihydro-1H-pyrazol-4-yl]-4-phenyl-2H-phthalazin-1-one 

Relevant articles and documents

Molecular docking and biological assessment of substituted phthalazin-1(2H)-one derivatives

2, 4-Disubstituted phthalazin-1(2H)-one derivatives were synthesized via nucleophilic attack of N-2 of phthalazin-1(2H)-one derivatives on different alkyl halides. In addition, reactive phthalazinone acetohydrazide derivative was utilized as a scaffold to synthesize different heterocyclic systems. The assigned structures for all the newly synthesized derivatives were confirmed on the basis of elemental analyses and spectral data. Mechanistic illustrations for some of the synthesized compounds were also discussed. The synthesized compounds were evaluated for in vitro antimicrobial and antitumor activity. Most of the tested compounds exhibited significant potency as antimicrobial and antitumor agents. Moreover, MOE 2014.09 software was utilized to carry out computational studies to support the biological activity results.

Synthesis and pharmacology of 1-oxo-pyridazine- and 1-oxo-phthalazine-2-acetic acid derivatives

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