1260813-24-8

Basic information

• Product Name: 5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole
• Synonyms: 5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole
• CAS NO: 1260813-24-8
• Molecular Weight: 225.195
• Mol File: 1260813-24-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole(1260813-24-8)
• EPA Substance Registry System: 5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole(1260813-24-8)

Safety Data

• Hazardous Substances Data: 1260813-24-8(Hazardous Substances Data)

Upstream product

• 189347-40-8 4,4-difluoro-1-(4-methoxy-phenyl)-butane-1,3-dione 

Downstream Products

• 1418197-33-7 2,2-difluoro-2-[3-(4-methoxyphenyl)isoxazol-5-yl]-1-phenylethanol 
• 1418197-34-8 (5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(phenyl)methanol 
• 1418197-35-9 2,2-difluoro-1-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)isoxazol-5-yl]ethanol 
• 1418197-36-0 (5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol 

Relevant articles and documents

Regioselective nucleophilic addition of 3-aryl-5-difluoromethyl-isoxazoles to aldehydes

A series of 5-difluoromethyl-isoxazoles 2 were prepared, and their regioselective nucleophilic addition to aldehydes was investigated. It was found that the nucleophilic difluoromethylation of aldehydes with 5-difluoromethyl-isoxazoles could be efficiently and uniquely achieved in the presence of LDA as a base that provides a large steric hindrance. In contrast, 3,4,5-trisubstituted 5-difluoromethyl isoxazoles were alternatively afforded as the sole product in moderate yields when n-BuLi was used as the base.