1261038-81-6Relevant articles and documents
Quinidine thiourea-catalyzed aldol reaction of unactivated ketones: Highly enantioselective synthesis of 3-alkyl-3-hydroxyindolin-2-ones
Guo, Qunsheng,Bhanushali, Mayur,Zhao, Cong-Gui
experimental part, p. 9460 - 9464 (2011/02/22)
New catalysis mechanism! The asymmetric aldol reaction of unactivated ketones and activated carbonyl compounds is realized with a quinidine-derived thiourea catalyst (see scheme), and involves an enolate mechanism instead of the widely used enamine mechan