1261168-15-3

Basic information

• Product Name: N-ethyl-3-(4-nitrophenyl)-1,2,4-oxadiazol-5-amine
• Synonyms: N-ethyl-3-(4-nitrophenyl)-1,2,4-oxadiazol-5-amine
• CAS NO: 1261168-15-3
• Molecular Weight: 234.214
• Mol File: 1261168-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-ethyl-3-(4-nitrophenyl)-1,2,4-oxadiazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-3-(4-nitrophenyl)-1,2,4-oxadiazol-5-amine(1261168-15-3)
• EPA Substance Registry System: N-ethyl-3-(4-nitrophenyl)-1,2,4-oxadiazol-5-amine(1261168-15-3)

Safety Data

• Hazardous Substances Data: 1261168-15-3(Hazardous Substances Data)

Upstream product

• 192332-48-2 N'-hydroxy-4-nitrobenzimidamide 
• 25952-53-8 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 

Relevant articles and documents

Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives

We describe herein a convenient straightforward synthesis of 5-amino-substituted 1,2,4-oxadiazoles, upon the reactions of amidoximes with carbodiimides, as well as their further derivatization to acetamides, in good yields. Most of the compounds exhibited in general low interaction with the stable radical 1,1-diphenyl-2-picryl-hydrazyl. Compounds 32 and 39 inhibited significantly soybean lipoxygenase. Selected compounds were screened for their in vivo anti-inflammatory activity using the carrageenin paw edema model and showed significant anti-inflammatory activity (26, 51%). The ability of the compounds to release NO in the presence of a thiol factor has been also investigated.