1261274-07-0

Basic information

• Product Name: (Z)-5-hydroxy-2-(4-carbamoylbenzylidene)benzofuran-3(2H)-one
• Synonyms: (Z)-5-hydroxy-2-(4-carbamoylbenzylidene)benzofuran-3(2H)-one
• CAS NO: 1261274-07-0
• Molecular Weight: 281.268
• Mol File: 1261274-07-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-5-hydroxy-2-(4-carbamoylbenzylidene)benzofuran-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-hydroxy-2-(4-carbamoylbenzylidene)benzofuran-3(2H)-one(1261274-07-0)
• EPA Substance Registry System: (Z)-5-hydroxy-2-(4-carbamoylbenzylidene)benzofuran-3(2H)-one(1261274-07-0)

Safety Data

• Hazardous Substances Data: 1261274-07-0(Hazardous Substances Data)

Upstream product

• 19278-82-1 5-hydroxy-2,3-dihydrobenzofuran-3-one 
• 6051-41-8 4-formylbenzamide 

Relevant articles and documents

Design, synthesis and discovery of 5-hydroxyaurone derivatives as growth inhibitors against HUVEC and some cancer cell lines

A series of 4′-substituted 5-hydroxyaurone derivatives were synthesized and their inhibitory activities against the proliferation of endothelial cells and two cancer cell lines were studied. Some of these compounds functioned as potent inhibitors against the proliferation of endothelial cells and cancer cells but possessed much weaker cytotoxic activities against non-cancer cell line of CCC-HPF-1. It was demonstrated that two most active compounds 16 and 27 effectively inhibited in vitro endothelial cell motility and tube formation, which are basic properties of endothelial cells for angiogenesis. Moreover, 16 and 27 also showed significant activities against in vitro cancer cell invasion, indicating that they have potential to inhibit cancer metastasis. These composite results suggest that 4′-substituted 5-hydroxyaurone is indeed a candidate structural scaffold for anticancer agent targeting activated endothelial cells and fast-proliferating cancer cells.