1261286-16-1Relevant articles and documents
Design and synthesis of novel retinoid synergists having a dibenzodiazepine skeleton
Ohta, Kiminori,Kawachi, Emiko,Shudo, Koichi,Kagechika, Hiroyuki
, p. 2465 - 2470 (2011/04/24)
Based on the structures of potent RXR agonists 2 and 3, novel dibenzodiazepine derivatives 4-6, containing two diphenylamine substructures, were designed as RXR modulator candidates and synthesized by utilizing Pd-catalyzed and Cu-promoted diphenylamine-generating reactions as key reactions. These compounds showed retinoid-synergistic activity, enhancing the HL-60 cell differentiation-inducing ability of the RAR agonist Am80. The Japan Institute of Heterocyclic Chemistry.