1261358-84-2

Basic information

• Product Name: 2-(4-cyanophenyl)-2,2-difluoro-acetic acid
• Synonyms: 2-(4-cyanophenyl)-2,2-difluoro-acetic acid
• CAS NO: 1261358-84-2
• Molecular Weight: 197.141
• Mol File: 1261358-84-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-(4-cyanophenyl)-2,2-difluoro-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-cyanophenyl)-2,2-difluoro-acetic acid(1261358-84-2)
• EPA Substance Registry System: 2-(4-cyanophenyl)-2,2-difluoro-acetic acid(1261358-84-2)

Safety Data

• Hazardous Substances Data: 1261358-84-2(Hazardous Substances Data)

Usage

Chemical structure

2,2-difluoroacetic acid core with a 4-cyanophenyl group attached at the 2-position.

Appearance

White to light yellow solid.

Solubility

Soluble in organic solvents.

Usage

Commonly used as a starting material or reagent in organic synthesis reactions.

Applications

Production of pharmaceuticals and agrochemicals, development of new drugs, and as a building block for complex organic molecules.

Precaution

Handle with caution due to potential hazardous properties from the presence of the cyanide group.

Upstream product

• 3058-39-7 4-iodobenzonitrile 
• 854778-10-2 2-(4-cyanophenyl)-2,2-difluoroacetic acid ethyl ester 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 55805-10-2 4-cyano-1-difluoromethylbenzene 

Relevant articles and documents

Silver-catalyzed decarboxylative radical allylation of α,α-difluoroarylacetic acids for the construction of CF2-allyl bonds

An efficient silver-catalyzed method of decarboxylative radical allylation of α,α-difluoroarylacetic acids to build CF2-allyl bonds has been developed. Using allylsulfone as an allyl donor, α,α-difluorine substituted arylacetic acids bearing various functional groups are successfully allylated to access a series of 3-(α,α-difluorobenzyl)-1-propylene compounds in moderate to excellent yields in aqueous CH3CN solution under the mild conditions. Experimental studies disclosed that the α-fluorine substitution of arylacetic acid has a great influence on free radical activity and reactivity.

USE OF SUBSTITUTED 1,2,4-OXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI

The present invention relates the use of compounds of the formula I, or their N-oxides, or the agriculturally acceptable salts thereof, for combating phytopathogenic harmful fungi. Further the present invention relates to agrochemical compositions compris

Controlling the cleavage of carbon-carbon bonds to generate α,α-difluorobenzyl carbanions for the construction of difluoromethylbenzenes

Controlling the cleavage of carbon-carbon bonds during a chemical reaction is a substantial challenge; however, synthetic methods that accomplish this objective produce valuable and often unexplored reactivity. We have designed a mild process to generate α,α-difluorobenzyl carbanions in the presence of potassium carbonate by exploiting the cleavage of C-C bonds during the release of trifluoroacetate. The initiating reagent is potassium carbonate, which represents an improvement over existing protocols that require a strong base. Fragmentation studies across substituted arenes and heteroarenes were conducted along with computational analyses to elucidate reactivity trends. Furthermore, the mildly generated α,α-difluorobenzyl carbanions from electron-deficient aromatics and heteroaromatic rings can react with aldehydes to create derivatives of difluoromethylbenzenes, which are valuable synthetic targets.