1261868-54-5Relevant articles and documents
Regioselective metalations of pyrimidines and pyrazines by using frustrated Lewis pairs of BF3×OEt2 and hindered magnesium- and zinc-amide bases
Groll, Klaus,Manolikakes, Sophia M.,Du Jourdin, Xavier Mollat,Jaric, Milica,Bredihhin, Aleksei,Karaghiosoff, Konstantin,Carell, Thomas,Knochel, Paul
, p. 6776 - 6780 (2013)
Born of frustration: Using the frustrated Lewis pairs TMP-metal and BF 3×OEt2 allows the regioselective metalation of pharmaceutically relevant diazines, such as pyrimidines, purines, and pyrazines. These metalations are often complementary to prior deprotonations performed without BF3×OEt2. Especially attractive is a new sequential regioselective full functionalization of the pyrazine scaffold with a bulky (TMS)2CH substituent. Copyright