1262802-05-0

Basic information

• Product Name: (E)-1-(4-bromo-2-nitrophenyl)ethanone O-methyl oxime
• Synonyms: (E)-1-(4-bromo-2-nitrophenyl)ethanone O-methyl oxime
• CAS NO: 1262802-05-0
• Molecular Weight: 273.086
• Mol File: 1262802-05-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-bromo-2-nitrophenyl)ethanone O-methyl oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-bromo-2-nitrophenyl)ethanone O-methyl oxime(1262802-05-0)
• EPA Substance Registry System: (E)-1-(4-bromo-2-nitrophenyl)ethanone O-methyl oxime(1262802-05-0)

Safety Data

• Hazardous Substances Data: 1262802-05-0(Hazardous Substances Data)

Upstream product

• 99-90-1 para-bromoacetophenone 

Downstream Products

• 90004-94-7 4’-bromo-2’-nitroacetophenone 

Relevant articles and documents

Palladium-catalyzed chelation-assisted aromatic C-H nitration: Regiospecific synthesis of nitroarenes free from the effect of the orientation rules

A palladium-catalyzed chelation-assisted ortho-nitration of aryl C-H bond is described. A range of azaarenes such as 2-arylquinoxalines, pyridines, quinoline, and pyrazoles were nitrated with excellent chemo- and regioselectivity. Using the O-methyl oximyl group as a removable directing group, the regiospecific synthesis of a variety of o-nitro aryl ketones was achieved starting from aryl ketones via a three-step process involving the Pd-catalyzed ipso-nitration of C-H bond as a key step. Mechanistic investigations support a silver-mediated radical mechanism involving Pd((II/III) and/or Pd(II/IV) catalytic cycles under oxidizing conditions.