1263000-56-1Relevant articles and documents
Alkylation of 2-methylquinoline with alcohols under additive-free conditions by Al2O3-supported Pt catalyst
Chaudhari, Chandan,Hakim Siddiki,Shimizu, Ken-Ichi
, p. 6490 - 6493 (2013)
Supported metal nanoparticle catalysts are studied for alkylation of 2-methylquinoline with benzyl alcohol under additive-free conditions in N 2 atmosphere. Among various metal-loaded Al2O3 catalysts and supported Pt catal
Iron-catalysed alkylation of 2-methyl and 4-methyl azaarenes with alcoholsviaC-H bond activation
Banerjee, Debasis,Bera, Sourajit,Kabadwal, Lalit Mohan
supporting information, p. 4777 - 4780 (2020/05/13)
The first Fe-catalysed alkylation of 2-methyl and 4-methyl-azaarenes with a series of alkyl and hetero-aryl alcohols is reported (>39 examples and up to 95% yield). Multi-functionalisation of pyrazines and synthesis of anti-malarial drug (±) Angustureine significantly broaden the scope of this methodology. Preliminary mechanistic investigation, deuterium labeling and kinetic experiments including trapping of the enamine intermediate1a'are of special importance.
Nickel-catalysed alkylation of C(sp3)-H bonds with alcohols: direct access to functionalised N-heteroaromatics
Vellakkaran, Mari,Das, Jagadish,Bera, Sourajit,Banerjee, Debasis
supporting information, p. 12369 - 12372 (2018/11/20)
The first base-metal catalysed coupling of primary alcohols with methyl-N-heteroaromatics is reported. The use of an earth abundant and nonprecious NiBr2/L1 system enables access to a series of C(sp3)-alkylated N-heteroaromatics. Mechanistic studies have established the participation of a hydrogen-borrowing strategy for α-alkylation.
