126301-37-9

Basic information

• Product Name: Benzenepropanesulfonic acid, b-amino-, (R)-
• CAS NO: 126301-37-9
• Molecular Formula: C9H13NO3S
• Molecular Weight: 215.273
• Mol File: 126301-37-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzenepropanesulfonic acid, b-amino-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanesulfonic acid, b-amino-, (R)-(126301-37-9)
• EPA Substance Registry System: Benzenepropanesulfonic acid, b-amino-, (R)-(126301-37-9)

Safety Data

• Hazardous Substances Data: 126301-37-9(Hazardous Substances Data)

Upstream product

• 54-12-6 Trp 
• 126301-19-7 (2R)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl methanesulfonate 
• 19901-50-9 methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate 
• 106454-69-7 N-tert-butoxycarbonyl-D-Phenylalaninol 
• 77184-95-3 (R)-2-benzylaziridine 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 
• 126301-28-8 (R)-2-amino-3-phenylpropyl methanesulphonate hydrochloride 

Relevant articles and documents

A new and expeditious asymmetric synthesis of (R)- and (S)-2-aminoalkanesulfonic acids from chiral amino alcohols

The mechanism for the transformation of β-amino alcohol methanesulfonate hydrochlorides into sodium β-amino alkanesulfonates using sodium sulfite was investigated. The results show that sodium sulfite initially neutralizes the β-amino alcohol methanesulfonate hydrochloride to give a free β-amino alcohol methanesulfonate, which then cyclizes to a 2-alkylaziridine. Attack by the previously formed sodium bisulfite at the less hindered carbon atom of the aziridine ring then yields a β-amino alkanesulfate sodium salt. Based on this mechanistic proposal, a new and rapid asymmetric synthesis of (R)- and (S)-2-aminoalkanesulfonic acids from chiral amino alcohols was developed. Chiral amino alcohols were converted to chiral aziridines through the Wenker method or Mitsunobu reaction and the resulting aziridines were reacted with sodium bisulfite to produce chiral β-amino alkanesulfonic acids.

Syntheses and Properties of Optically Active 2-Substituted Taurines

The synthesis of nine 2-substituted taurines (5a-i), including the marine natural product D-cysteinolic acid (5f), are described.These involve the successive conversion of N-t-butoxycarbonyl(Boc)-protected amino acid esters (1) into the N-Boc-2-aminoethanols (2), their O-mesylated derivatives (3), the deprotected 2-aminoethyl methanesulphonates (4), followed by the replacement of the mesyloxy group by a sulpho group to give the optically active taurines (5a-e,g-i).Hydrogenolysis of 2-benzyloxymethyltaurine (5e) gives D-cysteinolic acid (5f).The structure of another of the products, (5b), is also confirmed by an alternative synthesis from N-Boc-valine methyl ester (1b) via twoβ-bromoethylamine derivatives, (6b) and (7b).