1263048-46-9 Usage
Description
(S)-N-Boc-2-(4'-pentenyl)alanine is a chemical compound with a molecular formula C15H25NO4. It is a derivative of the amino acid alanine, featuring a 4'-pentenyl group attached to the alpha carbon and a Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom. (S)-N-Boc-2-(4'-pentenyl)alanine is significant in the field of organic chemistry and pharmaceuticals due to its unique structural properties and applications.
Uses
Used in Pharmaceutical Industry:
(S)-N-Boc-2-(4'-pentenyl)alanine is used as a building block for the synthesis of peptide molecules, particularly in the solid-phase peptide synthesis (SPPS) process. The Boc group acts as a protective moiety, enabling selective deprotection and subsequent coupling reactions during peptide assembly. (S)-N-Boc-2-(4'-pentenyl)alanine is valuable for designing and synthesizing peptide-based pharmaceuticals and chemical probes.
Used in Chemical Research:
(S)-N-Boc-2-(4'-pentenyl)alanine is used as a research compound for studying the effects of the 4'-pentenyl side chain on the chemical and physical properties of peptides. This knowledge can be applied to develop novel peptide-based drugs with improved properties, such as enhanced stability, bioavailability, or target specificity.
Used in Organic Chemistry:
(S)-N-Boc-2-(4'-pentenyl)alanine serves as a versatile intermediate in organic synthesis, allowing chemists to explore various synthetic routes and functional group transformations. (S)-N-Boc-2-(4'-pentenyl)alanine's unique structure makes it a useful tool for developing new synthetic methods and strategies in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1263048-46-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,3,0,4 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1263048-46:
(9*1)+(8*2)+(7*6)+(6*3)+(5*0)+(4*4)+(3*8)+(2*4)+(1*6)=139
139 % 10 = 9
So 1263048-46-9 is a valid CAS Registry Number.
1263048-46-9Relevant articles and documents
Stabilized alpha helical peptides and uses thereof
-
Sheet 2, (2016/05/19)
Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
Monosubstituted alkenyl amino acids for peptide "stapling"
Yeo, David J.,Warriner, Stuart L.,Wilson, Andrew J.
, p. 9131 - 9133 (2013/09/24)
Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
