1263193-21-0Relevant articles and documents
Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors
Asproni, Battistina,Murineddu, Gabriele,Pau, Amedeo,Pinna, Gérard A.,Langg?rd, Morten,Christoffersen, Claus Tornby,Nielsen, Jacob,Kehler, Jan
experimental part, p. 642 - 649 (2011/02/27)
A series of phenylimidazole-pyrazolo[1,5-c]quinazolines 1a-q was designed, synthesized and characterised as a novel class of potent phophodiesterase 10A (PDE10A) inhibitors. In this series, 2,9-dimethyl-5-(2-(1-methyl-4-phenyl-1H- imidazol-2-yl)ethyl)pyrazolo[1,5-c]quinazoline (1q) showed the highest affinity for PDE10A enzyme (IC50 = 16 nM).
