1263374-32-8 Usage
Description
4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL is a chemical compound that serves as a key intermediate in the synthesis of various pharmaceuticals, particularly CDK9 inhibitors. It is characterized by its unique molecular structure, which includes an aminomethyl group and a tetrahydro-2H-pyran-4-carbonitrile moiety, along with a hydrochloride (HCL) salt form. 4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL plays a crucial role in the development of therapeutic agents targeting specific cellular pathways.
Uses
Used in Pharmaceutical Industry:
4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL is used as a key intermediate for the synthesis of CDK9 inhibitors. These inhibitors are important in the development of therapeutic agents for various diseases, including cancer. CDK9 is a protein that plays a role in the regulation of cell cycle progression and transcription, and its inhibition can lead to the suppression of tumor growth and the prevention of cancer progression.
In the synthesis of CDK9 inhibitors, 4-(AMINOMETHYL)TETRAHYDRO-2H-PYRAN-4-CARBONITRILE HCL serves as a building block that can be further modified and optimized to enhance the potency, selectivity, and pharmacokinetic properties of the resulting inhibitors. By targeting CDK9, these inhibitors can potentially disrupt the cellular processes that contribute to the development and progression of cancer, offering a promising avenue for the treatment of various malignancies.
Check Digit Verification of cas no
The CAS Registry Mumber 1263374-32-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,3,3,7 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1263374-32:
(9*1)+(8*2)+(7*6)+(6*3)+(5*3)+(4*7)+(3*4)+(2*3)+(1*2)=148
148 % 10 = 8
So 1263374-32-8 is a valid CAS Registry Number.
1263374-32-8Relevant articles and documents
CERTAIN CHEMICAL COMPOSITIONS AND METHODS OF USE THEREOF
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Paragraph 0153; 0155-0156, (2021/11/20)
The present disclosure provides CDK9 inhibitors. Also provided are methods of treating a disease or a disorder comprising administering to a subject in need of treatment one of the CDK9 inhibitors disclosed herein. In some embodiments, the disease or diso
3-(AMINOARYL)-PYRIDINE COMPOUNDS
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Page/Page column 89, (2012/06/01)
The present invention provides a compound of formula (I): and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof. Also provided are pharmaceutical compositions containing these compounds and methods of treating a disease or condition mediated by CDK9 using these compounds and compositions.
PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES
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Page/Page column 85, (2012/08/08)
The present invention provides a pyrimidine compound of formula (I): wherein one of X and Y but not both is N, and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tantomers, diastereomers, deuterated versions, or racemates thereof. These compounds inhibit the activity of CDK9 and are thus useful as pharmaceuticals. Also provided are methods of treating a disease or condition mediated by CDK9 using the compounds of Formula I and isomers thereof, and pharmaceutical compositions comprising such compounds
