126353-32-0 Usage
Description
2-bromo-1-pyrazin-2-yl-ethanone hydrobromide is a dark brown solid that serves as an essential intermediate in the synthesis of various organic compounds. It is a chemical compound with the molecular structure that includes a pyrazine ring and a bromo-ketone functional group, which makes it a valuable building block in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
2-bromo-1-pyrazin-2-yl-ethanone hydrobromide is used as a synthetic intermediate for the development of potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines. These compounds exhibit dual histamine H3 antagonist/serotonin transporter inhibitor activity, which makes them promising candidates for the treatment of various central nervous system disorders, such as attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, and schizophrenia.
Additionally, due to its unique chemical structure, 2-bromo-1-pyrazin-2-yl-ethanone hydrobromide can be further modified and utilized in the synthesis of other bioactive molecules with potential applications in the pharmaceutical industry. Its versatility as a synthetic building block allows researchers to explore its use in creating novel drugs with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 126353-32-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,3,5 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 126353-32:
(8*1)+(7*2)+(6*6)+(5*3)+(4*5)+(3*3)+(2*3)+(1*2)=110
110 % 10 = 0
So 126353-32-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H5BrN2O.BrH/c7-3-6(10)5-4-8-1-2-9-5;/h1-2,4H,3H2;1H
126353-32-0Relevant articles and documents
BACE INHIBITORS
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Page/Page column 23, (2014/05/24)
The present invention provides compounds of Formula I useful as BACE inhibitors in the treatment of e.g. Alzheimer's disease : wherein A is selected from the group consisting of; of; R1 is H or F; R2 is H, -OCH3, C1-C3 alkyl,; R3 is H, -CH3, or -OCH3; and R4 is H or F; or a pharmaceutically acceptable salt thereof.
ARYL SUBSTITUTED IMIDAZO [4,5-C] PYRIDINE COMPOUNDS AS C3A RECEPTOR ANTAGONISTS
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Page/Page column 59, (2010/11/26)
Aryl substituted imidazo[4,5-c] pyridine compounds of formula (I) or pharmaceutically acceptable salt thereof are provided. These compounds are useful in pharmaceutical compositions as C3a antagonists for treating a variety of medical conditions associated with the Complement cascade.