126354-59-4

Basic information

• Product Name: [2-(4-Benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid diethyl ester
• Synonyms: [2-(4-Benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid diethyl ester
• CAS NO: 126354-59-4
• Molecular Weight: 423.406
• Mol File: 126354-59-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [2-(4-Benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(4-Benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid diethyl ester(126354-59-4)
• EPA Substance Registry System: [2-(4-Benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-ethoxymethyl]-phosphonic acid diethyl ester(126354-59-4)

Safety Data

• Hazardous Substances Data: 126354-59-4(Hazardous Substances Data)

Upstream product

• 26661-13-2 4-N-benzoylcytosine 
• 116384-57-7 Diethyl 2-Bromoethoxymethanephosphonate 

Downstream Products

• 126354-60-7 1-(2-Phosphonylmethoxyethyl)-5-methylcytosine disodium salt 

Relevant articles and documents

SYNTHESIS OF N-(2-PHOSPHONYLMETHOXYETHYL) DERIVATIVES OF HETEROCYCLIC BASES

The preparation of N-(2-phosphonylmethoxyethyl) derivatives of purine and pyrimidine bases, IV, as analogs of the antiviral 9-(2-phosphonylmethoxyethyl)adenine (PMEA,I), is described.The synthesis consists in alkylation of alkali metal salts of heterocyclic bases or their N- or O-substituted derivatives with diethyl 2-p-toluenesulfonyloxyethoxymethylphosphonate (IIa), 2-chloroethoxymethylphosphonate (IIb) or 2-bromoethoxymethylphosphonate (IIc).The obtained N-(2-diethoxyphosphonylmethoxyethyl) derivatives of heterocyclic bases (III) were treated with bromotrimethylsilane to give phosphonic acids IV.Compounds IV were prepared from pyrimidines (uracil, cytosine and their 5-methyl derivatives), purines (adenine and its N6- and C(2)-substituted derivatives, hypoxanthine, guanine, 6-hydrazinopurine and 6-methylthiopurine etc.) and their analogs (3-deazaadenine etc.).