126495-72-5Relevant articles and documents
A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis
Miles, Zachary D.,Diethelm, Stefan,Pepper, Henry P.,Huang, David M.,George, Jonathan H.,Moore, Bradley S.
, p. 1235 - 1242 (2017)
Bacterial meroterpenoids constitute an important class of natural products with diverse biological properties and therapeutic potential. The biosynthetic logic for their production is unknown and defies explanation via classical biochemical paradigms. A l
A total synthesis of xestodecalactone A and proof of its absolute stereochemistry: Interesting observations on dienophilic control with 1,3-disubstituted nonequivalent allenes
Yoshino, Toshiharu,Ng, Fay,Danishefsky, Samuel J.
, p. 14185 - 14191 (2008/02/10)
A concise total synthesis of xestodecalactone A, utilizing a Diels-Alder strategy is described. The focal Diels-Alder reaction relied on an "ynoate" dienophile to rapidly assemble the required resorcylinic acid scaffold. During this study, Diels-Alder cycloaddition reactions involving 1,3-disubstituted nonequivalent allene dienophiles were studied, and some surprising results were encountered.
DEOXYGENATION IN THE BIOSYNTHESIS OF POLYKETIDES: MECHANISM OF BIOMIMETIC REDUCTION OF TETRAHYDROXYNAPHTHALENE
Ichinose, Koji,Ebizuka, Yutaka,Sankawa, Ushio
, p. 2873 - 2875 (2007/10/02)
A biomimetic synthesis of scytalone, a simple derivative of tetralone, was reinvestigeted using NMR spectroscopy.Scytalone was formed from 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by sodium borohydride reduction only in the presence of sodium methoxi