1266338-13-9

Basic information

• Product Name: N-(3-chloro-4-(2-methylbenzamido)phenyl)picolinamide
• CAS NO: 1266338-13-9
• Molecular Weight: 365.819
• Mol File: 1266338-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-chloro-4-(2-methylbenzamido)phenyl)picolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chloro-4-(2-methylbenzamido)phenyl)picolinamide(1266338-13-9)
• EPA Substance Registry System: N-(3-chloro-4-(2-methylbenzamido)phenyl)picolinamide(1266338-13-9)

Safety Data

• Hazardous Substances Data: 1266338-13-9(Hazardous Substances Data)

Upstream product

• 252019-65-1 tert-butyl N-[(tert-butoxy)carbonyl]-N-(2-chloro-4-nitrophenyl)carbamate 
• 252019-51-5 N¹,N¹-bis(tert-butoxycarbonyl)-2-chloro-p-phenylenediamine 
• 121-87-9 2-Chloro-4-nitroaniline 
• 1308655-78-8 N-(3-chloro-4-aminophenyl)-2-picolinamide 
• 933-88-0 ortho-toluoyl chloride 
• 1308656-31-6 bis(tert-butyl 2-chloro-4-(picolinamido)phenyl)carbamate 

Relevant articles and documents

Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats

Herein we report the discovery, synthesis, and evaluation of a series of N-(4-acetamido)-phenylpicolinamides as positive allosteric modulators of mGlu4. Compounds from the series show submicromolar potency at both human and rat mGlu4. In addition, pharmacokinetic studies utilizing subcutaneous dosing demonstrated good brain exposure in rats.