126671-71-4 Usage
Description
8-Hydroxy Ondansetron is a metabolite of Ondansetron, which is a specific serotonin (5-HT3) receptor antagonist. It is primarily known for its antiemetic properties, making it a valuable compound in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
8-Hydroxy Ondansetron is used as an active pharmaceutical ingredient for the development of antiemetic medications. It serves as a key component in formulations designed to alleviate nausea and vomiting associated with various conditions, such as chemotherapy, radiation therapy, and postoperative recovery.
Used in Research Applications:
In addition to its practical use in medicine, 8-Hydroxy Ondansetron is also utilized in research settings. It is employed as a research tool to study the mechanisms of serotonin receptor antagonism and its effects on the central nervous system. This helps scientists better understand the role of serotonin in nausea and vomiting, potentially leading to the development of more effective treatments.
Used in Drug Development:
8-Hydroxy Ondansetron plays a role in the drug development process, as it can be used to evaluate the efficacy and safety of new compounds targeting the 5-HT3 receptor. By comparing the properties and actions of these new compounds with those of 8-Hydroxy Ondansetron, researchers can gain insights into their potential therapeutic benefits and side effects.
Overall, 8-Hydroxy Ondansetron is a versatile compound with applications in the pharmaceutical industry, research, and drug development, primarily due to its role as a metabolite of the antiemetic agent Ondansetron and its interaction with the serotonin (5-HT3) receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 126671-71-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,6,7 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 126671-71:
(8*1)+(7*2)+(6*6)+(5*6)+(4*7)+(3*1)+(2*7)+(1*1)=134
134 % 10 = 4
So 126671-71-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H19N3O2/c1-11-19-8-9-21(11)10-12-6-7-14-16(18(12)23)13-4-3-5-15(22)17(13)20(14)2/h3-5,8-9,12,22H,6-7,10H2,1-2H3
126671-71-4Relevant articles and documents
Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition
Worboys,Brennan,Bradbury,Houston
, p. 897 - 907 (1996)
The kinetics of hydroxylation and N-demethylation of ondansetron have been determined in freshly isolated hepatocytes, hepatic microsomes and precision-cut liver slices from the male Sprague-Dawley rat. In vivo studies have also been carried out to characterize the pharmacokinetics of ondansetron and in vitro data have been assessed for their value as predictors of hepatic clearance. In the three in vitro systems, the formation of hydroxylated and demethylated metabolites were characterized as a function of substrate concentration by a high-affinity, low-capacity site and a low-affinity, high-capacity site which was not saturated over the concentration range studied (2.5-500 μM). Slices gave consistently higher K(m)'s (20 and 30 μM for hydroxylation and demethylation respectively) than hepatocytes (3 and 13 μM respectively) and microsomes (2 and 5 μM respectively). The rank order of V(max) and CL(int) was the same for each system; hydroxylation rates exceeding demethylation rates. Although two hydroxylations (7- and 8-hydroxy metabolites) occurred exclusively in microsomes, these are believed to originate from a common precursor. The high CL(int) of ondansetron (150 ml/min/SRW, where SRW is a standard rat weight of 250 g) is well predicted by scaling either microsomal clearance for microsomal protein recovery or hepatocyte clearance for hepatocellularity (212 and 135 ml/min/SRW respectively). In contrast, the use of liver slice data scaled to a whole liver substantially underestimates CL(int) (9 ml/min/SRW).
