1267808-41-2Relevant articles and documents
PROCESS FOR GALNAC OLIGONUCLEOTIDE CONJUGATES
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Page/Page column 21-22, (2018/12/13)
The invention comprises a process for the preparation of therapeutically valuable GalNAc cluster oligonucleotide conjugates. The process comprises the coupling of an alkali metal salt, earth alkali metal salt or a tetraalkylammonium salt of an oligonucleotide with a GalNAc cluster compound or with a salt thereof and a subsequent purification.
GalNAc CLUSTER PHOSPHORAMIDITE
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Page/Page column 15; 16, (2017/06/12)
The invention comprises Gal NAc phosphoramidite derivatives of the formula (I), wherein R1 is a hydroxy protecting group, n is an integer from 0 to 10 and m is an integer from 0 to 20 and its corresponding enantiomers and/ or optical isomers thereof. The invention further comprises a process for the preparation of the Gal NAc phosphoramidite derivatives of the formula (I) and its use in the preparation of therapeutically valuable GalNAc-cluster oligonucleotide conjugates.
COMPOSITIONS FOR TARGETED DELIVERY OF SIRNA
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Paragraph 0161, (2016/03/05)
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide m