126832-81-3

Basic information

• Product Name: 1-PYRIDIN-4-YLPIPERIDIN-4-ONE
• Synonyms: 1-PYRIDIN-4-YLPIPERIDIN-4-ONE;2,3,5,6-TETRAHYDRO-[1,4']BIPYRIDINYL-4-ONE;1-(4-Pyridinyl)-4-piperidinone
• CAS NO: 126832-81-3
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.21508
• Mol File: 126832-81-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 340.797 °C at 760 mmHg
• Flash Point: 159.908 °C
• Appearance: /
• Density: 1.164 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 10.54±0.10(Predicted)
• CAS DataBase Reference: 1-PYRIDIN-4-YLPIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PYRIDIN-4-YLPIPERIDIN-4-ONE(126832-81-3)
• EPA Substance Registry System: 1-PYRIDIN-4-YLPIPERIDIN-4-ONE(126832-81-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 126832-81-3(Hazardous Substances Data)

Usage

General Description

1-Pyridin-4-ylpiperidin-4-one is a chemical compound with the molecular formula C11H14N2O. It is a heterocyclic compound that contains a piperidin-4-one ring and a pyridine ring. 1-Pyridin-4-ylpiperidin-4-one is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various biologically active compounds, including pharmaceutical drugs and agrochemicals. Its structural features make it a versatile intermediate for the construction of complex molecules with diverse pharmacological properties. 1-Pyridin-4-ylpiperidin-4-one may also have potential applications in materials science and other industrial processes due to its unique chemical structure and reactivity.

Upstream product

• 166954-75-2 8-(pyridin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 19524-06-2 4-bromopyridine hydrochloride 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 7379-35-3 4-chlorpyridine hydrochloride 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 74129-11-6 4-bromopyridine hydrobromide salt 
• 1120-87-2 4-bromopyridin 

Downstream Products

• 1235971-79-5 4-(4-benzyl-piperazin-1-yl)-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl 
• 1235971-67-1 4-(4-phenyl-piperazin-1-yl)-3,4,5,6-tetrahydro-2H-[1,4']-bipyridinyl 
• 1365135-35-8 (3R)-3-[(2-chlorobenzoyl)amino]-N-[(1-pyridin-4-ylpiperidin-4-yl)methyl]-2,3-dihydro-1H-indene-5-carboxylic acid amide 

Relevant articles and documents

Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation

Glucokinase (GK) activators are being developed for the treatment of type 2 diabetes mellitus (T2DM). However, existing GK activators have risks of hypoglycemia caused by over-activation of GK in islet cells and dyslipidemia caused by over-activation of intrahepatic GK. In the effort to mitigate risks of hypoglycemia and dyslipidemia while maintaining the promising efficacy of GK activator, we investigated a series of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific partial GK activators, which led to the identification of compound 72 that showed a good balance between in vitro potency and enzyme kinetic parameters, and protected β-cells from streptozotocin-induced apoptosis. Chronic treatment of compound 72 demonstrated its potent activity in regulation of glucose homeostasis and low risk of dyslipidemia with diabetic db/db mice in oral glucose tolerance test (OGTT). Moreover, acute treatment of compound 72 did not induce hypoglycemia in C57BL/6J mice even at 200 mg/kg via oral administration.

PIPERIDIN-4-YLPIPERAZINE COMPOUNDS FOR THE TREATMENT OF HCV INFECTION

The invention relates to new piperazine-pieridine compounds having anti-viral activity and particularly anti-HCV activity. The invention further relates to pharmaceutical compositions comprising compounds according to the invention.

Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 exhibited potent inhibitory activity against factor Xa (FXa) and good selectivity with respect to other serine