126875-81-8

Basic information

• Product Name: Guanosine, 2'-deoxy-8-[(4-methoxyphenyl)amino]-
• CAS NO: 126875-81-8
• Molecular Formula: C17H20N6O5
• Molecular Weight: 388.383
• Mol File: 126875-81-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Guanosine, 2'-deoxy-8-[(4-methoxyphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Guanosine, 2'-deoxy-8-[(4-methoxyphenyl)amino]-(126875-81-8)
• EPA Substance Registry System: Guanosine, 2'-deoxy-8-[(4-methoxyphenyl)amino]-(126875-81-8)

Safety Data

• Hazardous Substances Data: 126875-81-8(Hazardous Substances Data)

Upstream product

• 66682-84-6 N-(4-Methoxyphenyl)acetohydroxamsaeure 
• 961-07-9 2'-Deoxyguanosine 
• 126875-78-3 (N^α-Benzylglycin)-N-(4-methoxyphenyl)hydroxamsaeure 
• 126901-22-2 (N^α-Benzylalanin)-N-(4-methoxyphenyl)hydroxamsaeure 
• 1124321-46-5 8N-(4-methoxyphenylamino)-3',5'-bis(tert-butyldimethylsilyl)-2'-deoxyguanosine 
• 1124321-46-5 C₂₉H₄₈N₆O₅Si₂ 

Downstream Products

• 1125587-10-1 N₂-formamidino-8N-(4-methoxyphenylamino)-2'-deoxyguanosine 

Relevant articles and documents

Synthesis of DNA strands site-specifically damaged by C8-arylamine purine adducts and effects on various DNA polymerases

C8-Arylamine-dG and C8-arylamine-dA adducts have been prepared using palladium cross-coupling chemistry. These adducts were subsequently converted into the corresponding 5′-O-DMTr-C8-arylamine-3′-O-phosphoramidites and then used for the automated synthesi

N-Aryl-O-(α-aminoacyl)hydroxylamines: Model Reactions with Deoxyguanosine, Guanosine and 5'-Guanosinemonophosphate for the Activation of Monocyclic Aromatic Amines (e.g. Phenacetin) into Ultimate Carcinogens

In in vitro model reactions of the activation of monocyclic aromatic amines by α-amino acids it is shown that α-aminohydroxamic acids 8 and 9 rearrange base-catalyzed to N-(α-aminoacyloxy)arylamines 10 and 11 which react with bionucleophiles such as deoxyguanosine (dG) (12), guanosine (G) (13) and 5'-guanosinemonophosphate (5'-GMP) (14) to form adducts.We describe the regioselective formation of the C-8 adducts of 4-chloroaniline (15), aniline (16), 4-methylaniline (17), and 4-methoxyaniline (18), respectively, , and also of N-(guanosine-8-yl)-4-methylaniline (21) and 8-(4-methylanilino)-5'-guanosinemonophosphate (22).Similar reactions of the N-(acetoxy)arylamines 20, which are very likely to be "ultimate" carcinogens of aromatic amines, lead to the same C-8 adducts 15-18, 21, and 22 in comparable yields.These in vitro reactions thus show that the N-(α-aminoacyloxy)arylamines 10 and 11 react like the N-(acetoxy)anilines 20 as "ultimate" carcinogens.Therefore, the activation of aromatic hydroxylamines by O-α-aminoacylation is of similar quality as by O-acetylation.