1268869-16-4Relevant articles and documents
A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents
Wang, Xu,Pan, Ying-Ming,Huang, Xiao-Chao,Mao, Zhong-Yuan,Wang, Heng-Shan
supporting information, p. 2028 - 2032 (2014/03/21)
A novel, simple, and efficient method for the synthesis of 4,5-dihydropyrazole derivatives has been developed. The reaction proceeded through the base-induced isomerization of easily accessible propargyl alcohols followed by cyclization of α,β-unsaturated hydrazones. Furthermore, selected compounds 3ab and 3ac exhibited good activities against Bel-7404 (human hepatoma cancer), HepG2 (human liver cancer), NCI-H460 (human lung cancer) and SKOV3 (human ovarian cancer) cell lines with IC50 in the range of 22-46 μmol L-1.
Transformations of 3-aryl-2-chloro-2-imidoylaziridines: Novel entries to 4-chloro-2,5-diaryl-1H-imidazoles and 2-chloro-2-acylaziridines
Colpaert, Filip,Mangelinckx, Sven,Giubellina, Nicola,De Kimpe, Norbert
experimental part, p. 1258 - 1265 (2011/04/16)
The reactivity of stereochemically defined 3-aryl-2-chloro-2- imidoylaziridines, an unexplored class of substituted aziridines, was investigated under various reaction conditions. 2-Chloro-2-imidoylaziridines underwent a novel thermal rearrangement by reflux in acetonitrile via C-C bond cleavage to 4-chloro-2,5-diarylimidazoles in high yield. Alternatively, a novel efficient entry toward 2-aroyl-2-chloroaziridines was based on the chemoselective hydrolysis of 2-chloro-2-imidoylaziridines with hydrochloric acid in aqueous tetrahydrofuran.
