126934-94-9

Basic information

• Product Name: methyl 2-(3,4-methylenedioxyphenyl)propionate
• Synonyms: methyl 2-(3,4-methylenedioxyphenyl)propionate
• CAS NO: 126934-94-9
• Molecular Weight: 208.214
• Mol File: 126934-94-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: methyl 2-(3,4-methylenedioxyphenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3,4-methylenedioxyphenyl)propionate(126934-94-9)
• EPA Substance Registry System: methyl 2-(3,4-methylenedioxyphenyl)propionate(126934-94-9)

Safety Data

• Hazardous Substances Data: 126934-94-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 7315-32-4 5-vinyl-1,3-benzodioxole 
• 201230-82-2 carbon monoxide 
• 2815-95-4 3-(1,3 benzodioxol-5-yl)propionic acid 
• 326-59-0 benzo[1,3]dioxol-5-yl-acetic acid methyl ester 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1234378-94-9 1-(2-(benzo[d][1,3]dioxol-5-yl)-2-methylpropylidene)-2-phenylhydrazine 
• 1234378-83-6 4-(1-(acetoxyimino)-2-methylpropan-2-yl)-1,2-phenylene diacetate 
• 1234378-80-3 2-(3,4-dihydroxyphenyl)-2-methylpropanal oxime 
• 1018781-60-6 methyl 2-[4,5-methylenedioxy-2-(3-methyl-4-nitrobenzoyl)-phenyl]propionate 
• 197369-16-7 methyl 2-[2-(4-nitrobenzoyl)-4,5-methylenedioxy-phenyl]propionate 
• 877171-08-9 3,5-dihydro-5-methyl-7,8-methylenedioxy-1-(4-nitrophenyl)-4H-2,3-benzodiazepin-4-one 
• 197368-83-5 1-(4-aminophenyl)-5-methyl-7,8-methylenedioxy-3,5-dihydro-2,3-benzodiazepin-4(4H)-one 
• 24314-70-3 methyl (S)-(+)-2-(3,4-methylenedioxyphenyl)propionate 
• 24314-70-3 methyl (R)-(-)-2-(3,4-methylenedioxyphenyl)propionate 

Relevant articles and documents

Palladium-Catalyzed Asymmetric Markovnikov Hydroxycarbonylation and Hydroalkoxycarbonylation of Vinyl Arenes: Synthesis of 2-Arylpropanoic Acids

Asymmetric hydroxycarbonylation is one of the most fundamental yet challenging methods for the synthesis of carboxylic acids. Herein, we reported the development of a palladium-catalyzed highly enantioselective Markovnikov hydroxycarbonylation of vinyl arenes with CO and water. A monodentate phosphoramidite ligand L6 plays vital role in the reaction. The reaction tolerates a range of functional groups, and provides a facile and atom-economical approach to an array of 2-arylpropanoic acids including several commonly used non-steroidal anti-inflammatory drugs. The catalytic system has also enabled an asymmetric Markovnikov hydroalkoxycarbonylation of vinyl arenes with alcohols to afford 2-arylpropanates. Mechanistic investigations suggested that the hydropalladation is irreversible and is the regio- and enantiodetermining step, while hydrolysis/alcoholysis is probably the rate-limiting step.

Stereodivergent coupling of aldehydes and alkynes via synergistic catalysis using Rh and Jacobsen's amine

We report an enantioselective coupling between α-branched aldehydes and alkynes to generate vicinal quaternary and tertiary carbon stereocenters. The choice of Rh and organocatalyst combination allows for access to all possible stereoisomers with high enantio-, diastereo-, and regioselectivity. Our study highlights the power of catalysis to activate two common functional groups and provide access to divergent stereoisomers and constitutional structures.

SUBSTITUTED CATHECHOLS AS INHIBITORS OF IL-4 AND IL-5 FOR THE TREATMENT BRONCHIAL ASTHMA

The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.