1269662-77-2

Basic information

• Product Name: (E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinazolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine
• Synonyms: (E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinazolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine
• CAS NO: 1269662-77-2
• Molecular Weight: 469.946
• Mol File: 1269662-77-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinazolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinazolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine(1269662-77-2)
• EPA Substance Registry System: (E)-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinazolin-6-yl]-3-[(2R)-1-methylpyrrolidin-2-yl]propan-2-enoylamine(1269662-77-2)

Safety Data

• Hazardous Substances Data: 1269662-77-2(Hazardous Substances Data)

Upstream product

• 59378-81-3 1-(tert-butoxycarbonyl)prolin-2R-ol 
• 3554-65-2 (R)-N-methylpyrrolidine-2-methanol 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 1269662-90-9 N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine 
• 1269662-83-0 diethyl [({4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}carbamoyl)methyl]phosphonate 
• 852324-28-8 (2R)-1-methylpyrrolidine-2-formaldehyde 

Relevant articles and documents

6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The present disclosure relates to 6-amino quinazoline or 3-cyano quinoline derivatives, preparation processes and pharmaceutical compositions containing them. Specifically, the present disclosure relates to novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by formula (I), or its tautomer, enantiomer, diastereomer, racemate or pharmaceutically acceptable salts thereof, or metabolite, metabolic precursor or prodrug thereof, and the uses for treatment especially for protein kinase inhibitors, in which each substitute group of general formula (I) is as defined in the specification.

6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.