127-76-4 Usage
Description
4'-(thiazol-2-ylsulphamoyl)acetanilide is a sulfonamide derivative characterized by the presence of a benzenesulfonamide core, which is substituted by an acetylamino group at the 4th position and a 1,3-thiazol-2-yl group at the nitrogen atom. 4'-(thiazol-2-ylsulphamoyl)acetanilide is known to be a metabolite of sulfathiazole, a widely used antibiotic.
Uses
Used in Pharmaceutical Industry:
4'-(thiazol-2-ylsulphamoyl)acetanilide is used as an intermediate compound in the synthesis of various pharmaceuticals, particularly antibiotics. Its unique chemical structure allows it to be a valuable building block for the development of new drugs with improved properties and enhanced efficacy.
Used in Research and Development:
In the field of medicinal chemistry and drug discovery, 4'-(thiazol-2-ylsulphamoyl)acetanilide serves as a key research compound. Scientists and researchers utilize this molecule to study its potential interactions with biological targets, such as enzymes and receptors, which can lead to the discovery of novel therapeutic agents.
Used in Chemical Synthesis:
4'-(thiazol-2-ylsulphamoyl)acetanilide is also employed as a synthetic building block in the preparation of various organic compounds. Its versatile structure enables chemists to modify and functionalize it in various ways, leading to the creation of new molecules with diverse applications in different industries.
Flammability and Explosibility
Notclassified
Check Digit Verification of cas no
The CAS Registry Mumber 127-76-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 127-76:
(5*1)+(4*2)+(3*7)+(2*7)+(1*6)=54
54 % 10 = 4
So 127-76-4 is a valid CAS Registry Number.
127-76-4Relevant articles and documents
Synthesis, antimicrobial, and docking investigations of remarkably modified sulfathiazole derivatives
Gaballah, Samir T.,Amer,Hofinger-Horvath,Al-Moghazy,Hemida
, p. 171 - 184 (2020/04/09)
SOME new sulfathiazole derivatives were synthesized. The sulfathiazole starting material was reacted with ethyl bromoacetate and gave unpredictably an ester product 2. The substitution occurred selectively at the tautomeric proton of the NH thiazolyl nitrogen rather than the aromatic NH2 protons. The ester was further hydrazinolysed followed by condensation with several aldehydes to establish hydrazones (4a-h). Hantzesch thiazole synthesis was also applied to build antimicrobial agents containing multi-thiazole moieties. The structures of the synthesized compounds were confirmed by 1H, 13C, 2D 1H NMR, MS, and microanalyses. The synthesized compounds were tested for their antimicrobial activity towards Gram-positive and Gram-negative bacteria, and fungi strains. Some of the investigated compounds showed prominent high potency. The docking study revealed the mode of action between the modified sulfathiazole ligands and the binding site of DHPS.