127060-60-0Relevant articles and documents
Preparation method of thioether derivative
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Paragraph 0078-0081, (2021/08/28)
The invention discloses a preparation method of a thioether derivative, which comprises the following steps: (1) in a nitrogen atmosphere, mixing a sulfoxide compound, an olefin compound/alkyne compound/1, 3-dicarbonyl compound, an organic solvent and trifluoroacetic anhydride/trifluoromethanesulfonic anhydride, and reacting at 0-60 DEG C for 1-24 hours; (2) adding alkali into the material obtained in the step (1), reacting at room temperature for 0.5-1.5 hours, and washing with water to obtain an organic phase; and (3) carrying out post-treatment and purification on the organic phase obtained in the step (2) to obtain the thioether derivative. The method is suitable for constructing alkenyl thioether, alkynyl thioether and alkyl thioether derivatives at the same time, and is high in universality. The method has the advantages of easily available raw materials, high yield, mild reaction conditions, short reaction time, wide substrate range, strong reaction specificity, and simple and green post-treatment.
Ru-Catalyzed [3 + 2] Cycloaddition of Nitrile Oxides and Electron-Rich Alkynes with Reversed Regioselectivity
Feng, Qiang,Huang, Hai,Sun, Jianwei
supporting information, p. 2431 - 2436 (2021/05/05)
Polarity reversal ("umpolung") of a functional group can override its inherent reactivity and lead to distinct bond-forming modes. Herein we describe a rarely studied cycloaddition between nitrile oxides and electron-rich alkynes with reversed regioselect
Accessing the Rare Diazacyclobutene Motif
Narangoda, Chandima J.,Lex, Timothy R.,Moore, Madelyn A.,McMillen, Colin D.,Kitaygorodskiy, Alex,Jackson, James E.,Whitehead, Daniel C.
supporting information, p. 8009 - 8013 (2019/01/04)
A formal [2 + 2] cycloaddition of 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) with electron-rich alkynyl sulfides and selenides is described. These investigations provide a convenient method to access diazacyclobutenes in good yield while tolerating a rela