127073-84-1

Basic information

• Product Name: (R)-3-iodo-1-phenyl-1-propanol
• Synonyms: (R)-3-iodo-1-phenyl-1-propanol
• CAS NO: 127073-84-1
• Molecular Weight: 262.09
• Mol File: 127073-84-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (R)-3-iodo-1-phenyl-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-iodo-1-phenyl-1-propanol(127073-84-1)
• EPA Substance Registry System: (R)-3-iodo-1-phenyl-1-propanol(127073-84-1)

Safety Data

• Hazardous Substances Data: 127073-84-1(Hazardous Substances Data)

Usage

Description

(R)-3-iodo-1-phenyl-1-propanol is an organic compound belonging to the class of alcohols, characterized by a phenyl group attached to a propanol molecule with an iodine atom at the third position. (R)-3-iodo-1-phenyl-1-propanol is distinguished by its asymmetric carbon center, which endows it with unique stereochemical properties.

Uses

Used in Pharmaceutical Industry:
(R)-3-iodo-1-phenyl-1-propanol is used as a chiral building block for the synthesis of various pharmaceuticals. Its asymmetric carbon center allows for the creation of specific stereoisomers, which can be crucial in the development of drugs with targeted effects and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, (R)-3-iodo-1-phenyl-1-propanol is utilized as a key component in the synthesis of certain agrochemicals. Its stereochemical properties enable the production of compounds with specific biological activities, contributing to the development of more effective and targeted agrochemical products.
Used in Chemical Research:
(R)-3-iodo-1-phenyl-1-propanol is also used in chemical research, particularly in the field of radiochemistry. The presence of the iodine atom makes it a potentially valuable tool for radiochemical labeling and related research applications, facilitating the study of chemical reactions and processes at the molecular level.
Used in Organic Synthesis:
(R)-3-iodo-1-phenyl-1-propanol is employed as an intermediate in organic synthesis, where its unique structural features can be exploited to construct a wide range of complex organic molecules. Its versatility in synthesis makes it a valuable asset in the development of new chemical products and materials.

Upstream product

• 103548-16-9 (R)-3-phenyl-1,3-dihydroxypropane 
• 936-59-4 3-chloropropiophenone 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 

Downstream Products

• 155675-18-6 3-Phenyl-propionic acid (R)-3-iodo-1-phenyl-propyl ester 
• 168465-69-8 (R)-α-(2-azidoethyl)benzenemethanol 
• 319924-88-4 (R)-6-methyl-3,4-dihydro-2-phenyl-2H-1-benzopyran 
• 319924-88-4 (S)-6-methyl-3,4-dihydro-2-phenyl-2H-1-benzopyran 
• 1132755-87-3 (R)-3,4-dihydro-2-phenyl-2H-1-benzopyran 
• 157968-59-7 (S)-3,4-dihydro-2-phenyl-2H-1-benzopyran 
• 54910-89-3 (R)-fluoxetine 
• 695229-16-4 C₁₆H₁₄INOS 
• 114247-09-5 (R)-fluoxetine hydrochloride 
• 570384-27-9 [4-(3-amino-1-phenyl-propoxy)-phenyl]-p-tolyl-methanone 
• 138750-31-9 (1R)-3-amino-1-phenyl-1-propanol 
• 115290-81-8 (R)-N-methyl-3-phenyl-3-hydroxypropylamine 
• 155675-30-2 (R)-3-Benzyloxy-butyric acid (R)-3-iodo-1-phenyl-propyl ester 

Relevant articles and documents

A method for preparing optically active 3-amino-1-phenylpropanol derivatives as an intermediate and a method for preparing optically active pharmaceutical products using the same

The present invention relates to a method for preparing a 3-amino-1-phenylpropanol derivative having (R) or (S) optical activity with 80% or more of an enantiomeric excess (ee), which includes a step of performing an asymmetric reduction reaction in the presence of a spiroborate ester catalyst and a hydrogen donor. The invention also relates to a method for preparing an optically active pharmaceutical product, which includes a step of preparing a (R)- or (S)-3-amino-1-phenylpropanol derivative, that is an intermediate, by using the catalyst.(AA) 3-amino-1-phenylpropanol(BB) Tomoxetine(CC) Nisoxetine(DD) FluoxetineCOPYRIGHT KIPO 2016

Copper(ii)-catalyzed enantioselective hydrosilylation of halo-substituted alkyl aryl and heteroaryl ketones: Asymmetric synthesis of (R)-fluoxetine and (S)-duloxetine

A set of reaction conditions has been established to facilitate the non-precious copper-catalyzed enantioselective hydrosilylation of a number of structurally diverse β-, γ- or ε-halo-substituted alkyl aryl ketones and α-, β- or γ-halo-substituted alkyl heteroaryl ketones under air to afford a broad spectrum of halo alcohols in high yields and good to excellent enantioselectivities (up to 99% ee). The developed procedure has been successfully applied to the asymmetric synthesis of antidepressant drugs (R)-fluoxetine and (S)-duloxetine, which highlighted its synthetic utility.

7-PHENYL-ISOQUINOLINE-5-SULFONYLAMINO DERIVATIVES AS INHIBITORS OF AKT (PROTEINKINASE B)

The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.