127094-71-7

Basic information

• Product Name: 2,5-Morpholinedione,3-methyl-,(3S)-(9CI)
• Synonyms: 2,5-Morpholinedione,3-methyl-,(3S)-(9CI)
• CAS NO: 127094-71-7
• Molecular Formula: C5H7NO3
• Molecular Weight: 129.11
• Product Categories: GLYCINESCAFFOLD
• Mol File: 127094-71-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 446.7±38.0 °C(Predicted)
• Appearance: /
• Density: 1.212±0.06 g/cm3(Predicted)
• PKA: 12.71±0.40(Predicted)
• CAS DataBase Reference: 2,5-Morpholinedione,3-methyl-,(3S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Morpholinedione,3-methyl-,(3S)-(9CI)(127094-71-7)
• EPA Substance Registry System: 2,5-Morpholinedione,3-methyl-,(3S)-(9CI)(127094-71-7)

Safety Data

• Hazardous Substances Data: 127094-71-7(Hazardous Substances Data)

Usage

Structure

cyclic diketone with a morpholine ring

Uses

versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds; building block for heterocyclic compounds; potential applications in medicinal chemistry

Stereochemistry

(3S)-(9CI) designation indicating a specific three-dimensional arrangement of atoms.

Upstream product

• 691-80-5 (S)-2-(2-chloroacetamido)propanoic acid 

Relevant articles and documents

Biodegradable photocrosslinkable poly(depsipeptide-co-caprolactone) for tissue engineering: Synthesis, characterization, and in vitro evaluation

Stereolithography has become increasingly popular in scaffold fabrication due to automation and well-controlled geometry complexity, and consequently, there is a great need for new suitable biodegradable photocrosslinkable polymers. In this study, a new type of photocrosslinkable poly(ester amide) was synthesized based on e-caprolactone and L-alaninederived depsipeptide and was applied to fabrication of threedimensional (3D) scaffolds by stereolithography. 1H nuclear magnetic resonance and Fourier transform infra-red analysis confirmed the formation of new bonds during the polymer synthesis. Incorporation of depsipeptide increased the glass transition temperature and hydrophilicity of the polymer and accelerated hydrolytic degradation compared with the poly(ecaprolactone) homopolymer. The compressive strength of the 3D scaffolds increased with the increasing depsipeptide content. This work demonstrated that incorporation of depsipeptide into photocrosslinkable polyesters resulted in excellent cytocompatibility and tunable degradation rates and mechanical properties and thus expanded the repertoire of biomaterials suitable for 3D photofabrication of high-resolution tissue engineering scaffolds.