1271523-34-2

Basic information

• Product Name: 1,5-dichloro-2-iodo-3-methoxybenzene
• Synonyms: 1,5-dichloro-2-iodo-3-methoxybenzene
• CAS NO: 1271523-34-2
• Molecular Weight: 302.927
• Mol File: 1271523-34-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,5-dichloro-2-iodo-3-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-dichloro-2-iodo-3-methoxybenzene(1271523-34-2)
• EPA Substance Registry System: 1,5-dichloro-2-iodo-3-methoxybenzene(1271523-34-2)

Safety Data

• Hazardous Substances Data: 1271523-34-2(Hazardous Substances Data)

Usage

Type of compound

Halogenated benzene derivative

Halogen atoms

Chlorine and iodine

Halogen attachment

Attached to the benzene ring

Methoxy group

Attached to the 3 position

Uses

Intermediate in the synthesis of various organic compounds

Industry applications

Pharmaceutical industry, agrochemicals, and materials science

Health and environmental risks

Potential risks if not properly managed

Handling and disposal

Requires careful handling and disposal to minimize risks

Upstream product

• 1028332-19-5 3,5-dichloro-2-iodophenol 
• 77-78-1 dimethyl sulfate 
• 33719-74-3 3,5-dichloroanisole 

Downstream Products

• 1271523-45-5 3-amino-5-(2,4-dichloro-6-methoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one 
• 1271523-41-1 tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate 
• 1046862-08-1 2-(2,4-dichloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Preparation process of 3,5-dichloro-2-iodoanisole

The invention relates to a preparation process of 3,5-dichloro-2-iodoanisole. The preparation process comprises the following steps: sequentially adding 3,5-dichlorophenol and an organic solvent into a container, adding alkali at low temperature, carrying out uniform stirring, then recovering the temperature of a system to room temperature, performing stirring and reacting for quantitative time, slowly adding iodine at low temperature, gradually recovering to room temperature, conducting stirring overnight, quenching a reaction with acid, adding ethyl acetate for extraction, combining organic layers to obtain an intermediate product 3,5-dichloro-2-iodophenol, sequentially adding 3,5-dichloro-2-iodophenol, alkali and an organic solvent into the container, adding a methylation reagent, carrying out stirring for a reaction overnight under the condition of nitrogen protection, pouring reaction liquid into ice water, adding an organic solvent for extraction, and finally combining organic layers to obtain the final product 3, 5-dichloro-2-iodoanisole. The method is mild in reaction conditions, low in raw material price and free of dangerous goods, and has great advantages when being put into large-batch production.

Regioselective iodination of chlorinated aromatic compounds using silver salts

The iodination of chlorinated aromatic compounds using Ag 2SO4/I2, AgSbF6/I2, AgBF4/I2, and AgPF6/I2 offers access to iodoarenes that are valuable intermediates in organic synthesis. Specifically, iodination of phenols, anisoles, and anilines with a 3,5-dichloro substitution pattern preferentially yielded the ortho, para, and para iodinated product, respectively. In the case of chlorobenzene and 3-chlorotoluene, AgSbF6/I2, AgBF4/I2, and AgPF 6/I2, but not Ag2SO4/I2, selectively introduced the iodine in para position to the chlorine substituent.